摘要
目的:探讨扩散加权成像(DWI)对宫颈癌放化疗疗效的评估价值。方法:46名接受全程放化疗治疗的宫颈癌患者分别在治疗前、治疗2周后、外照射25次后及治疗结束后进行盆腔常规MRI及DWI扫描,每次扫描均测量肿瘤的直径及ADC值。根据治疗结束6个月后的随访结果将患者划分为完全有效组(CR)、部分有效组(PR)及无效组(SD)。计算并两两比较各次MRI扫描测得的肿瘤ADC值及直径的动态变化值。结果:CR组在治疗2周及外照射25次的ADC值提高均高于RP组及SD组(P<0.05),治疗结束后CR组的ADC值与PR组及SD组间差异均有统计学意义(P<0.05)。治疗前、放化疗2周后及外照射25次后各肿瘤组(CR、PR、SD组)的ADC值、肿瘤最大直径之间差异均无统计学意义(P>0.05)。结论:DWI可作为预测及监测宫颈癌放化疗疗效的有效方法。
Objective：To investigate the value of magnetic resonance diffusion weighted imaging （DWI）to predict and monitor the response to radiochemotherapy for cervical cancer.Methods：Forty-six patients with cervical cancer treated with radiochemotherapy underwent conventional MRI and DWI before treatment,in two weeks after treatment,after 25 fractions pelvic external beam radiotherapy （EBRT）and after the whole course of treatment.Treatment response was classified as complete response （CR）,partial response （PR）and stable disease （SD）,which was determined according to the changes in tumor size in 6 months after the whole treatment.Dynamic changes of apparent diffusion coefficients （ADC）and tumor size in the three groups were observed and compared.Results：The increase rate of ADC was higher in CR group than in PR and SD groups in two weeks treatment and after 25 fractions EBRT （P＆lt;0.05）.The ADC values were significantly different be-tween CR and PR groups,and between CR and SD groups after the whole course of treatment （P＆lt;0.05）.Among the three groups （CR,PR,SD group）,there were no significant differences in ADC and tumor size in two weeks treatment and after 25 fractions EBRT.Conclusion：DWI can be used to predict and monitor the response to radiochemotherapy in cervical canc-er.
出处
《放射学实践》
2014年第11期1306-1310,共5页
Radiologic Practice
关键词
磁共振成像
扩散加权成像
放化疗
宫颈肿瘤
Magnetic resonance imaging
Diffusion weighted imaging
Radiochemotherapy
Cervical neoplasms
