摘要
目的:探讨氨氯地平联合阿托伐他汀治疗老年急性脑梗死高血压的临床疗效。方法:86例急性脑梗死高血压患者随机分为观察组与对照组,每组43例。对照组给予苯磺酸氨氯地平片5 mg,po,qd,观察组在对照组基础上加用阿托伐他汀片20 mg,po,qd。治疗1个月后比较两组患者疗效及神经功能缺损评分、血压、血脂、C反应蛋白(CRP)等指标变化情况。结果:治疗后,观察组急性脑梗死总有效率明显高于对照组(P<0.05);降压总有效率明显优于对照组(P<0.05)。治疗后两组神经功能缺损评分均明显高于治疗前(P<0.05),且观察组评分明显高于对照组(P<0.05)。两组患者血压均较前明显降低(P<0.05),且观察组较对照组下降更明显(P<0.05)。治疗后观察组TC、TG、LDL-C和CRP等指标水平较治疗前明显降低(P<0.05),也明显低于对照组(P<0.05)。结论:使用氨氯地平联合阿托伐他汀治疗老年急性脑梗死高血压,效果显著,不良反应少,值得推广应用。
Objective： To discuss the effect of amlodipine combined with atorvastatin in the treatment of elderly patients with acute cerebral infarction hypertension. Methods： Totally 86 cases with acute cerebral infarction hypertension were randomly divided into the treatment group（ 43 cases） and the control group（ 43 cases）. The control group received amlodipine 5mg,po,qd,and the treatment group was given atorvastatin 20 mg additionally,po,qd. After the one-month treatment,the efficacy of the two groups was studied and compared,and the changes in neural function defect scale,blood pressure,blood lipids and CRP were also investigated. Results： After the treatment,the total effective rate and the total effective rate of antihypertensive effect in the treatment group were both significantly higher than those in the control group（ P〈0. 05）. The neurological deficit scores of the two groups were significantly higher than those before the treatment（ P〈0. 05）,and those of the observation group was significantly higher than those of the control group（ P〈0. 05）. The blood pressure of the two groups was both decreased after the treatment（ P〈0. 05）,and the decrease in the treatment group was more significant（ P〈0. 05）. TC,TG,LDL-C and CRP levels of the two groups had significant decrease after the treatment（ P〉0. 05）,and those in the treatment group was significant lower than those in the control group（ P〈0. 05）. Conclusion： Amlodipine combined atorvastatin in the treatment of elderly patients with acute cerebral infarction hypertension shows significant effect with low incidence of adverse drug reaction,which is worthy of wider application.
出处
《中国药师》
CAS
2014年第12期2075-2077,共3页
China Pharmacist
关键词
氨氯地平
阿托伐他汀
急性脑梗死高血压
Amlodipine
Atorvastatin
Acute cerebral infarction hypertension
