摘要
目的：探讨术前外周血血小板与淋巴细胞比值（PLR）与非小细胞肺癌患者临床病理特征的相关性及其对患者预后的影响。方法：回顾性分析2004年1月至2007年12月在济宁医学院附属医院行根治性手术切除并经病理诊断明确的255例非小细胞肺癌患者的临床病理资料。以PLR中位数将患者分为低PLR组和高PLR组，分析PLR与患者临床病理因素的相关性，单因素及多因素生存分析评价PLR对患者术后生存的影响。结果：全组患者术前PLR为45.45～272.66，中位值为130。低PLR组（≤130）127例，高PLR组（〉130）128例，PLR与肿瘤部位、T分期及临床分期相关（均P〈0.05）。低PLR组和高PLR组患者的5年生存率分别为49.6%和33.6%，差异有统计学意义（P〈0.001）；单因素分析结果显示：吸烟史、分化程度、临床分期、T分期、N分期、术后辅助治疗及PLR是患者预后的影响因素（均P〈0.05），多因素分析表明，N分期、术后辅助治疗及PLR是影响患者预后的独立危险因素（均P〈0.05）。分层分析显示，在无淋巴结转移及有淋巴结转移的患者中，低PLR与高PLR组患者的5年生存率差异均有统计学意义（P=0.020及0.037）。结论：术前PLR升高提示患者预后不良，是影响非小细胞肺癌患者预后的独立危险因素。
Objective：To investigate the correlation between preoperative blood platelet-to-lymphocyte ratio （PLR） and clinico-pathological features, as well as the effect of PLR on the prognosis of non-small cell lung cancer （NSCLC） patients after surgical resec-tion. Methods：Retrospective analysis was performed for 255 cases with histologically confirmed NSCLC that underwent curative re-section from January 2004 to December 2007. All patients were classified into two groups based on the median value of PLR. The rela-tionship between PLR and clinicopathological features was studied. Univariate and multivariate analyses were performed to assess the prognostic effect of preoperative PLR. Results：The median value of preoperative PLR was 130 （range：45.45 to 272.66）. Based on the cut-off value of 130, all patients were divided into two groups：low PLR （≤130, n=127） and high PLR （〉130, n=128）. PLR was corre-lated with tumor site, T stage, and clinical stage. Five-year survival rates of low and high PLR patients were 49.6%and 33.6%, respec-tively, which indicated a statistically significant difference （χ2=12.577, P〈0.001） between the two groups. Univariate analysis showed that smoking status, histological differentiation, clinical stage, T stage, N stage, postoperative adjuvant therapy and PLR were associat-ed with survival （P〈0.05 for all）. Multivariate analysis identified N stage, postoperative adjuvant therapy, and PLR as independent prog-nostic factors of all the patients. In addition, stratified analysis showed that the five-year survival rate of the low PLR group was higher than that of the high PLR group with or without lymph node metastasis, and the differences were statistically significant （P=0.020 and 0.037）. Conclusion：An elevated blood preoperative PLR indicates poor prognosis in NSCLC patients. Preoperative PLR is an indepen-dent prognostic factor of NSCLC after curative resection.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2014年第21期1374-1378,共5页
Chinese Journal of Clinical Oncology
关键词
非小细胞肺癌
血小板与淋巴细胞比值
预后
non-small cell lung cancer
platelet-to-lymphocyte ratio
prognosis
