摘要
目的:分析实体瘤患者化疗期间乙型肝炎病毒(hepatitis B virus,HBV)DNA的活化情况,了解初始不同HBV拷贝数患者之间化疗联合抗病毒治疗疗效、不良反应情况.方法:87例恶性肿瘤合并HBV感染者,根据其初始HBV DNA拷贝数随机分为两组,即初始HBV定量≥1×103GE/m L的患者44例,43例患者初始拷贝数<1×103GE/m L;常规化疗前1 wk给予抗病毒治疗,化疗结束后维持3 mo的抗病毒治疗.结果:初始HBV DNA拷贝数<1×103GE/m L组患者的Karnofsky功能状态(Karnofsky performance status,KPS)评分明显优于≥1×103G E/m L组患者;同时,两组患者在近期疗效方面比较相似,而远期疗效的比较发现,低拷贝组患者其6 mo以后的疾病进展和死亡风险相对更低,而化疗期间联合抗病毒并没有增加相关的不良反应.结论:对于恶性肿瘤合并HBV感染的患者,化疗期间联合抗病毒至关重要,这对于改善患者KPS、不良反应及远期疗效具有深远意义.
AIM: To understand the impact of different ini- tial hepatitis B virus (HBV) DNA copies on the efficacy and side effects of chemotherapy com- bined with antiviral therapy in tumor patients with hepatitis B. METHODS: Eighty-seven tumor patients with HBV infection were randomly divided into two groups according to the initial HBV DNA cop- ies: A and B. Group A included 44 patients with the initial HBV DNA copies 〉/ 1 x 103 GE/mL, while group B included 43 patients with the ini- tial HBV DNA copies 〈 1×103 GE/mL. All of the patients had been treated with antiviral therapy for one month before conventional chemothera- py and continued to receive antiviral therapy forthree months after chemotherapy RESULTS: The Karnofsky performance status (KPS) score was significantly higher in group B than in group A. The short-term therapeutic effects were similar between groups A and B, while in terms of long-term efficacy, the disease progression and death risk at 6 mo after chemo- therapy were significantly lower in group B than in group A. The rate of related side effects did not increase significantly during chemotherapy combined with antiviral therapy. CONCLUSION: For tumor patients with HBV infection, chemotherapy combined with antivi- ral therapy is superior to chemotherapy alone in terms of improving the KPS score and side ef- fects.
出处
《世界华人消化杂志》
CAS
北大核心
2014年第32期4985-4990,共6页
World Chinese Journal of Digestology