摘要
目的 建立SD大鼠孕期不伴有贫血的铁缺乏和轻度缺铁性贫血（IDA）的模型,并观察母体甲状腺功能的动态变化.方法 检测血红蛋白、血清铁、肝铁、甲状腺激素水平和甲状腺过氧化物酶（TPO）活性以及显微镜下甲状腺结构.结果 孕期轻度IDA和不伴有贫血的铁缺乏可以导致母鼠的TPO活性明显降低和母鼠低甲状腺素血症.铁缺乏导致甲状腺滤泡腔缩小,但没有破坏滤泡腔结构.结论 孕期铁缺乏可能是孕期母体低甲状腺素血症的病因之一,而孕期铁缺乏导致的低甲状腺素血症可能是孕期铁缺乏导致后代脑发育障碍的机制之一.
Objective To establish animal models of iron deficiency without anemia and mild iron deficiency anemia （IDA） in rat during pregnancy and to explore the dynamic changes in maternal thyroid function.Methods Hemoglobin,serum iron,liver iron,thyroid hormone,and thyroid peroxidase （TPO） activity were measured,and thyroid structure was examined under microscope.Results Both mild IDA and iron deficiency without anemia resulted in maternal hypothyroxinemia from mid-gestation to the end of pregnancy.TPO activity was significantly decreased even before reduction of liver iron concentrations in iron deficiency groups.Iron deficiency resulted in shrinkage of follicular cavities,but did not result in destruction of follicular structure.Conclusions Iron deficiency may be one of the etiological factors of maternal hypothyroxinemia,which could be one of the mechanisms of brain dysfunction caused by maternal iron deficiency.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2014年第11期995-998,共4页
Chinese Journal of Endocrinology and Metabolism
基金
国家自然科学基金资助项目（30800918）
关键词
铁缺乏
甲状腺激素
妊娠
Iron deficiency
Thyroid hormone
Pregnancy
