摘要
目的分析原发性中枢神经系统淋巴瘤的综合治疗方法和预后。方法确诊原发性中枢神经系统淋巴瘤患者39例,根据术后复查头颅CT或MR结果分为手术全切组(15例)和未全切组(24例),术后均给予同步放、化疗。治疗前后均对患者进行卡氏评分(KPS)并随访生存时间。结果全切组与未全切组在疾病的缓解程度上无统计学差异。KPS≥70分者的中位生存时间提高(P<0.05)。结论对原发性中枢神经系统淋巴瘤患者,需采用手术、放疗、化疗为主的综合治疗。手术全切病灶与否对预后无明显影响;KPS是预示患者生存期的一个重要指标。
Objective To analyze the clinical comprehensive therapy and the prognosis of patients with primary central nervous system lymphoma.Methods Data of 39 patients diagnosed as primary central nervous system lymphoma（PCNSL）were restropectively analyzed,who were divided into two groups of A（underwent total resection,15 cases）and B（underwent uncomplete resection,24 cases）on the basis of postoperative CT or MR imaging.The patients received synchronized radiochemistry therapy.Karnofsky performance status scoring was performed before and after treatment and survival rate was calculated by follow up.Results There was no obvious difference between two groups in disease remission.The median survival time was significantly increased in the patients with KPS≥70 points（P〈0.05）.Conclusion Comprehensive therapy including surgery and radiochemotherapy is needed for the patients with PCNSL.Whether the complete resection has been performed or not has no significant effect on the prognosis and KPS is an important indicator for predicting the survival time in the patients with PCNSL.
出处
《江苏医药》
CAS
北大核心
2014年第22期2703-2705,共3页
Jiangsu Medical Journal
关键词
原发性中枢神经系统淋巴瘤
卡氏评分
Primary central nervous lymphoma
Karnofsky performance status score
