期刊文献+

体检人群中慢性丙型肝炎患者临床特征研究 被引量:2

Study of Clinical Characteristics of Patients with Chronic Hepatitis C in Health Examination People
原文传递
导出
摘要 【目的】分析体检人群中慢性丙型肝炎(CHC)患者的临床特征,为CHC患者的早期诊断与治疗提供依据。【方法】回顾性分析体检人群中CHC患者的临床资料,并记录患者初次治疗时的 HCV‐RNA含量、丙肝病毒基因型及谷丙转氨酶(ALT)、谷草转氨酶(AST)、白蛋白(ALB)、血红蛋白(Hb)、血小板的(PLT)的水平。【结果】体检人群中共发现CHC患者58例,其中1b型占63.79%,2a型占17.24%,其他基因型占19.97%。体检人群CHC患者(HE组)与非体检发现的CHC患者(NHE组)相比,在HCV感染的危险因素、基因型分布、肝脏炎症相关指标方面均存在显著性差异( P <0.05)。【结论】体检人群中CHC患者HCV基因型以1b、2a型为主,ALT、AST、HCV‐RNA水平低于非体检发现的CHC患者。 [Objective] To analyze the clinical characteristics of patients with chronic hepatitis C (CHC) in health examination people in order to provide evidences for early diagnosis and treatment of CHC .[Methods]Clinical data of patients with chronic hepatitis C in health examination people were analyzed retrospectively . Hepatitis C virus(HCV)‐RNA level ,HCV genotype ,alanine transarninase(ALT) ,aspartate aminotransferase (AST) ,albumin(ALB) ,hemoglobin(Hb) and platelet(PLT) in treatment‐naive patients were determined .[Results] Among health examination people ,58 patients with CHC were found .The 1b genotype accounted 63 .79% ,and the 2a genotype accounted 17 .24% ,and other genotypes accounted 19 .97% .There were signif‐icant differences in the risk factors ,genotype distribution ,liver inflammation indexes and efficacy of HCV in‐fection between CHC patients of health examination people (HE) group and CHC patients of non‐health exami‐nation people(NHE) group( P〈0 .05) .[Conclusion] The main genotypes of HCV in CHC patients of health examination people are 1b and 2a .CHC patients of health examination people have the lower levels of ALT , AST and HCV‐RNA than those in CHC patients of non‐health examination people ,and its efficacy is better .
出处 《医学临床研究》 CAS 2014年第10期1873-1875,共3页 Journal of Clinical Research
基金 本研究受国家重点临床专科建设项目支持,项目编号财社[2010]305号
关键词 体格检查 肝炎 丙型 慢性 基因型 回顾性研究 Physical Examination Hepatitis C,Chronic Genotype Retrospective Studies
  • 相关文献

参考文献16

  • 1http://www, who. Int/mediacentre/factsheets/fs164/en/, 2014.
  • 2Tian Z. Outflanking HCV[J]. Nat Immunol, 2014, 15(1): 6-8.
  • 3HCH clinicians Network, chronic hepatitis C: silent intruder, insidious threat[J]. Healing hands, 1999,3(2) : 32.
  • 4Indolfi G, Bartotini E, Casavola D, et al . Chronic hepatitis C virus infection in children and adolescents: Epidemiulogy, natural history, and assessment of the safety and efficacy of combination therapy[J]. Adolesc Health Med Ther, 2010, 1 : 115-128.
  • 5丙型肝炎防治指南[J].临床肝胆病杂志,2004,20(4):197-203. 被引量:735
  • 6Simmonds P, Holmes EC, Cha TA, et al. Classification of hepatitis C virus into six major genotypes and a series of sub-types by phylogenetie analysis of the NS-5 region [J]. J Gene Virol, 1993, 74 ( Pt 11):2391-2399.
  • 7Simmonds P, Jens Bukh, Christophe Comber, et al . Consensus proposals for A unified system of nomenelature of hepatitis C virus genotypes[J]. Hepatology, 2005,42 (4) : 962-973.
  • 8苏迎盈,刘慧鑫,汪宁.中国丙型肝炎病毒基因型分布[J].中华流行病学杂志,2013,34(1):80-84. 被引量:90
  • 9谢尧,赵辉,鸥蔚妮,闫杰,杜邵财,徐道振.不同感染途径慢性丙型肝炎患者HCV基因型分布的差异[J].中华实验和临床病毒学杂志,2004,18(3):247-250. 被引量:30
  • 10Dong ZX,Zhou HJ,Wang JH, et al. Distribution of hepatitis C virus genotypes in Chinese patients with chronic hepatitis Ccorrelation with patients' characteristics and clinical param- eters [J].J Dig Dis, 2012, 13(11):564-570.

二级参考文献44

  • 1Yuan-Ding Chen,Ming-Ying Liu,Wen-Lin Yu,Jia-Qi Li,Mei Peng,Qing Dai,Xiao Liu Zhen-Quan Zhou From the Central Laboratory, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China Kunming Hospital for Infectious Diseases, Kunming 650041, China.Hepatitis C virus infections and genotypes in China[J].Hepatobiliary & Pancreatic Diseases International,2002,1(2):194-201. 被引量:18
  • 2杜绍财,陶其敏.丙型肝炎病毒基因5‘—末端非编码区酶切分型研究[J].中华医学杂志,1993,73(1):7-9. 被引量:45
  • 3施小明 ,梅志强 ,高建华 ,乔晓春 ,QIAN Han-zhu ,贾望谦 ,杨忠民 ,张玉良 ,郑锡文 ,汪宁 .山西省某既往有偿献血地区18~59岁村民丙型肝炎病毒感染的横断面研究[J].中华流行病学杂志,2005,26(11):864-867. 被引量:10
  • 4高玉红,李峥,台虹.丙型肝炎病毒基因分型方法研究进展[J].国际检验医学杂志,2006,27(10):908-910. 被引量:17
  • 5李峥,高玉红,台虹,毕胜,杨曦,张桂前.云南省丙型肝炎病毒基因的分型[J].中华传染病杂志,2007,25(4):246-247. 被引量:11
  • 6Camma C, Bruno S, Schepis F, et al. Retreatment with interferon plus ribavirin of chronic hepatitis C non- responders to interferon monotherapy: a meta- analysis of individual patient data[ J ]. Gut, 2002,51:864-869.
  • 7Papatheodoridis GV, Papadimitropoulos VC, Hsdziyannis SJ. Effect of interferon therapy on the development of hepatocellular carcinoma in patients with hepatitis C virus- reated cirrhosis: a meta- analysis[J] .Aliment Pnarmaool Ther, 2001,15:689- 698.
  • 8Kjaergard LL, Krogsgaard K, Gluud C. Interfern alfa with or without ribavirin for chronic hepatitis C: systematic review of randonmised trials[J].BMJ, 2001,323:1151 - 1155.
  • 9Alberti A, Benvegnu L. Management of hepatitis[J] .J Hepatol, 2003,38(Suppl1): S1014 - S1 18.
  • 10Poynard T, MdHutchison J, Davis GL, et al. Impact of interferon alfa - 2b and ribavirin on progression of liver fibrosiis in patients with chronic hepatitis C[J].Hepatology, 2000,32:1131 - 1137.

共引文献843

同被引文献22

引证文献2

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部