摘要
【目的】分析体检人群中慢性丙型肝炎(CHC)患者的临床特征,为CHC患者的早期诊断与治疗提供依据。【方法】回顾性分析体检人群中CHC患者的临床资料,并记录患者初次治疗时的 HCV‐RNA含量、丙肝病毒基因型及谷丙转氨酶(ALT)、谷草转氨酶(AST)、白蛋白(ALB)、血红蛋白(Hb)、血小板的(PLT)的水平。【结果】体检人群中共发现CHC患者58例,其中1b型占63.79%,2a型占17.24%,其他基因型占19.97%。体检人群CHC患者(HE组)与非体检发现的CHC患者(NHE组)相比,在HCV感染的危险因素、基因型分布、肝脏炎症相关指标方面均存在显著性差异( P <0.05)。【结论】体检人群中CHC患者HCV基因型以1b、2a型为主,ALT、AST、HCV‐RNA水平低于非体检发现的CHC患者。
[Objective] To analyze the clinical characteristics of patients with chronic hepatitis C (CHC) in health examination people in order to provide evidences for early diagnosis and treatment of CHC .[Methods]Clinical data of patients with chronic hepatitis C in health examination people were analyzed retrospectively . Hepatitis C virus(HCV)‐RNA level ,HCV genotype ,alanine transarninase(ALT) ,aspartate aminotransferase (AST) ,albumin(ALB) ,hemoglobin(Hb) and platelet(PLT) in treatment‐naive patients were determined .[Results] Among health examination people ,58 patients with CHC were found .The 1b genotype accounted 63 .79% ,and the 2a genotype accounted 17 .24% ,and other genotypes accounted 19 .97% .There were signif‐icant differences in the risk factors ,genotype distribution ,liver inflammation indexes and efficacy of HCV in‐fection between CHC patients of health examination people (HE) group and CHC patients of non‐health exami‐nation people(NHE) group( P〈0 .05) .[Conclusion] The main genotypes of HCV in CHC patients of health examination people are 1b and 2a .CHC patients of health examination people have the lower levels of ALT , AST and HCV‐RNA than those in CHC patients of non‐health examination people ,and its efficacy is better .
出处
《医学临床研究》
CAS
2014年第10期1873-1875,共3页
Journal of Clinical Research
基金
本研究受国家重点临床专科建设项目支持,项目编号财社[2010]305号
关键词
体格检查
肝炎
丙型
慢性
基因型
回顾性研究
Physical Examination
Hepatitis C,Chronic
Genotype
Retrospective Studies