摘要
目的:确定中药川贝对哮喘模型小鼠肺水肿和支气管炎症的影响。方法:建立哮喘小鼠模型并随机分为模型组(OVA致敏的小鼠),中药川贝组(中药川贝治疗的小鼠)和PBS组(正常对照组的小鼠)。结果:中药川贝可抑制哮喘模型小鼠肺水肿,降低BALFIL-1和IL-6水平,同时还可降低亚硝酸盐浓度和减轻中性粒细胞的浸润,并且使哮喘模型小鼠血清Ig E水平降低。结论:中药川贝通过抑制哮喘模型小鼠血清Ig E水平可减轻肺水肿及支气管中性粒细胞炎症。
Objective：To investigate the effect of Bulbus Fritillariae Cirrhosae on pulmonary inflammation in allergic asthma model mice.Methods：Murine asthma models were established and mice were divided into a model group （OVA-sensitized and challenged mice）,a BFC group （Bulbus Fritillariae Cirrhosae for mice） and a PBS group （normal control mice）.Results：Bulbus Fritillariae Cirrhosae inhibited pulmonary edema and decreased interleukin （IL）-1 and IL-6 levels in bronchoalveolar lavage fluid in OVA-treated mice.Bulbus Fritillariae Cirrhosae also decreased pulmonary nitrite level and neutrophil infiltration induced by OVA.Moreover,Bulbus Fritillariae Cirrhosae decreased serum IgE level in OVA-treated mice.Conclusion：Bulbus Fritillariae Cirrhosae may attenuate pulmonary edema and bronchial neutrophilic inflammation by inhibiting systemic IgE level in allergic asthma.
出处
《中医药信息》
2014年第6期19-22,共4页
Information on Traditional Chinese Medicine
基金
牡丹江医学院科学技术研究项目(No.2010-34)
