摘要
目的：探讨补肾通脉汤对慢性心力衰竭患者血浆肾素活性（PRA）、脑钠肽（BNP）和血管紧张素Ⅱ（AngⅡ）的影响。方法选取2011年1月至2013年12月山东省日照市中医医院心血管病科慢性心力衰竭患者100例，采用随机数字表法将患者分为两组，每组50例，对照组给予西医常规疗法，治疗组在对照组基础上加用补肾通脉汤治疗，均治疗8周。实验室检测治疗前后PRA、BNP、和AngⅡ，超声心动图评价治疗前后心功能。结果治疗组PRA、BNP、AngⅡ均较治疗前显著降低（t值分别为2.990、4.030、4.401，P均＜0.05）。治疗组治疗后PRA、BNP、AngⅡ显著低于对照组（t值分别为2.622、2.863、3.809，P均＜0.05）。两组超声心动图检测的左心室收缩末期直径（LVESD）、左心室舒张末期直径（LVEDD）和左心室射血分数（LVEF）均显著改善（治疗组t值分别为9.167、11.030、13.273，P均＜0.01；对照组分别为5.189、7.626、6.906，P均＜0.01）；治疗组LVESD、LVEDD、LVEF改善显著优于对照组，差异均有统计学意义（t＝4.037、2.701、7.458，P均＜0.01）。结论补肾通脉汤可有效降低慢性心衰患者PRA以及血浆BNP、AngⅡ水平，改善心功能。
Objective To investigate the effect of Bushen-Tongmai decoction on plasma renin activity （PRA）, plasma levels of brain natriuretic peptide （BNP） and angiotensinⅡ（AngⅡ） in patients with chronic heart failure. Methods A total of 100 patients with chronic heart failure from January 2011 to December 2013 were randomly divided into a control group and a treatment group, with 50 patients in each group. The patients in the control and treatment groups received conventional treatment and Bushen-Tongmai decoction plus conventional treatment for 8 weeks, respectively. Laboratory measurements including PRA, BNP and AngⅡwere performed before and after treatment.Cardiac function was measured before and after treatment with echocardiography. Results The PRA , plasma levels of BNP and AngⅡ after treatment in the treatment group were significantly decreased than before treatment （treatment group：t=2.990, 4.030, 4.401, all P〈0.01）;after treatment, there was significant difference in PRA, BNP and AngⅡbetween the treatment group and the control group（t=2.622, 2.863, 3.809, all P〈0.05）. Left ventricular end-diastolic diameter （LVEDD）, left ventricular end-systolic diameter （LVESD） and left ventricular ejection fraction （LVEF） by echocardiography in both groups were significantly improved （treatment group：t=9.167, 11.030, 13.273, all P＆lt;0.01;control group：t=5.189, 7.626, 6.906, all P〈0.01）. Improvements of LVESD, LVEDD and LVEF in the treatment group were grater than those in the control group （t=4.037, 2.701, 7.458, all P〈0.01）. Conclusion Bushen-Tongmai decoction can effectively decrease PRA , plasma levels of BNP, AngⅡ, and improve cardiac function in patients with chronic heart failure.
出处
《国际中医中药杂志》
2014年第12期1071-1073,共3页
International Journal of Traditional Chinese Medicine
关键词
补肾通脉汤
心力衰竭
肾素
利钠肽
脑
血管紧张素Ⅱ
超声心动描记术
Bushen-Tongmai decoction
Heart failure
Renin
Natriuretic peptide,Brain
Angiotensin Ⅱ
Echocardiography
