期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血清25-羟维生素D质量浓度对急诊脓毒症患者预后的影响 被引量：3

原文传递
导出
摘要 近年来，随着对维生素D的深入研究，人们发现维生素D不仅是经典的钙磷代谢调节剂，而且具有免疫调节作用。维生素D可通过对多种免疫细胞和细胞因子发挥作用来调控固有免疫和抑制适应性免疫应答，从而影响脓毒症的发生发展怛。目前，国际上常用血清25．羟维生素D[25（OH）D]作为衡量和监测维生素D含量的最佳指标。国外已有研究表明，25（OH）D缺乏可能增加危重症患者的病死率旧。还有研究显示25（OH）D不足会加重急诊脓毒症患者的病情。但国内尚无维生素D对急诊脓毒症患者影响的报道。本研究之目的在于探讨不同的25（OH）D质量浓度对急诊脓毒症患者预后的影响。
作者 贾育梅 赵永祯
机构地区 首都医科大学附属北京朝阳医院内分泌科 首都医科大学附属北京朝阳医院急诊科
出处 《中华急诊医学杂志》 CAS CSCD 北大核心 2014年第12期1389-1392,共4页 Chinese Journal of Emergency Medicine
关键词 脓毒症患者 维生素D 质量浓度 急诊 预后 血清 25(OH)D 免疫调节作用
分类号 R459.7 [医药卫生—急诊医学]
  • 相关文献

参考文献19

  • 1Hewison M.Vitamin D and the immune system:new perspectives on an old theme[J].Endocrinol Metab Clin North Am,2010,39(2):365-379.
  • 2彭霄,贺宏丽,邱海波.维生素D在脓毒症免疫调节中的作用研究进展[J].中华危重病急救医学,2014,26(3):206-208. 被引量：24
  • 3Venkatram S,Chilimuri S,Adrish M,et al.Vitamin D deficiency is associated with mortality in the medical intensive care unit[J].Crit Care,2011,15 (6):292-230.
  • 4Braun AB,Gibbons FK,Litonjua AA,et al.Low serum 25-hydroxyvitamin D at critical care initiation is associated with increased mortality[J].Crit Care Med,2012,40 (1):63-72.
  • 5Ginde AA,Camargo CA Jr,Shapiro NI.Vitamin D insufficiency and sepsis severity in emergency department patients with suspected infection[J].Acad Emerg Med,2011,18 (5):551-554.
  • 6Levy MM,Fink MP,Marshall JC,et al.2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference[J].Intensive Care Med,2003,29 (4):530-538.
  • 7Holick MF,Binkley NC,Bischoff-Ferrari HA,et al.Endocrine Society:Evaluation,treatment,and prevention of vitamin D deficiency:An Endocrine Society clinical practice guideline[J].J Clin Endocrinol Metab,2011,96 (7):1911-1930.
  • 8Amrein K,Zajic P,Schnedl C,et al.Vitamin D status and its association with season,hospital and sepsis mortality in critical illness[J].Critical Care,2014,18 (2):47-58.
  • 9Jeng L,Yamshchikov AV,Judd SE,et al.Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis[J].J Transl Med,2009,7 (1):28-36.
  • 10Nguyen HB,Rivers EP,Havstad S,et al.Critical care in the emergency department:a physiologic assessment and outcome evaluation[J].Acad Emerg Med,2000,7 (12):1354-1361.

二级参考文献63

  • 1侵袭性肺部真菌感染的诊断标准与治疗原则(草案)[J].中华内科杂志,2006,45(8):697-700. 被引量：867
  • 2Martin GS, Mannino DM, Eaton S, et al. The epidemiology of sepsis in the United States fi'om 1979 through 2000 [ J] . N Engl J Med, 2003, 348 (16) : 1546 -1554.
  • 3Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock [ J 1 ~ N Engl J Med, 2001, 345 (19) : 1368-1377.
  • 4Shapiro NI, Wolfe RE, Moore RB, et al. Emergency Department Sepsis (MEDS) score derived and validated clinical prediction rule [ J~ 2003, 31 (3) : 670-675. Mortality in the a prospectively Crit Care Med,.
  • 5Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ ACCP/ATS/SIS International Sepsis Definitions Conference [J]. Intensive Care Med, 2003, 29 (4): 530-538.
  • 6Buffer J. The surviving sepsis campaign and the emergency department [J] . Emerg Med J, 2008, 25 (1) : 2-3.
  • 7Knaus WA, Draper EA, Wagner DP, et al. APACHE Ⅱ: a severity of disease classification system [ J ] . Crit Care Med, 1985, 13 (10): 818-829.
  • 8Le Gall JR, Lemeshow S, Saulnier F. A new simplified acute physiology score (SAPS 1I ) based on a European/North American mnhicenter study [J] . JAMA, 1993, 270 (24): 2957-2963.
  • 9Ronny M, Otero, H, Nguyen B, et al. Early goal-directed therapy in severe sepsis and septic shock revisited [ J] . Chest, 2006, 130 (5) : 1579-1595.
  • 10Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis [ J ] . N Engl J Med, 2001, 344 (10) : 699-709.

共引文献101

同被引文献16

引证文献3

二级引证文献2

中华急诊医学杂志
2014年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部