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HSP70-2基因多态性与糖尿病肾病易感性的关系 被引量:1

Heat shock protein 70-2 gene polymorphism and susceptibility to diabetic nephropathy
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摘要 目的探讨HSP70-2(+1267A/G)基因多态性与2型糖尿病肾病的关系。方法收集河南省平顶山市152医院肾内科住院及行定期健康体检的人群资料,按照纳入与排除标准纳入研究对象共677例,其中2型糖尿病患者447例(糖尿病肾病组226例,糖尿病非肾病组221例),正常对照组230例。对研究对象进行一般情况问卷调查、体格检查及实验室生化指标检测,并采用PCR-RFLP技术分析HSP70-2基因(+1267A/G)多态性。结果糖尿病肾病组的HSP70-2基因G/G基因型频率高于糖尿病非肾病组和正常对照组,差异有统计学意义(χ2=8.123,P<0.01;χ2=11.651,P<0.01);糖尿病肾病组的G等位基因频率高于糖尿病非肾病组和正常对照组,差异有统计学意义(χ2=9.392,P<0.01,OR=1.782;χ2=11.971,P<0.01,OR=2.153)。G/G基因型携带者MALB/Cr和BMI水平高于A/A基因携带者,差异有统计学意义(P<0.05)。结论 HSP70-2基因1267位点G/G基因型可能与糖尿病肾病及全身性肥胖易感性相关;G等位基因增加了携带者患糖尿病肾病的风险。 Objective To investigate the relationship between heat shock protein 70-2(HSP70-2) gene polymorphism and diabetic nephropathy(DN) in patients with type 2 diabetes mellitus(T2DM).Methods Following the inclusion and exclusion criteria,a total of 677 subjects were enrolled in present study.They were either hospitalized or undergoing regular health check-up in the Department of Nephrology of PLA 152 nd Hospital in Pingdingshan of Henan Province.Among them 226 patients were suffering from diabetes mellitus and nephrosis(DN+ group),221 patients with T2 DM but without nephrosis(DN– group),and 230 were normal controls(NC group).Data were collected by questionnaire,physical examination and laboratory examination,and polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique was applied to detect the single nucleotide polymorphisms of HSP70-2(+1267/G).Results The G/G genotype frequency of HSP70-2 was significantly higher in DN+ group than in DN– and NC group(χ2=8.123,P〈0.01;χ2=11.651,P〈0.01);the G allele frequency of HSP70-2 was significantly higher in DN+ group than in DN – and NC group(χ2=9.392,P〈0.01,OR=1.782;χ2=11.971,P〈0.01,OR=2.153).The levels of MALB/Cr and BMI were significantly higher in G/G gene carriers than in A/A gene carriers(P〈0.05).Conclusion The G/G genotype of HSP70-2(+1267) may be related to susceptibility to DN and general obesity;G allele carrier may have increased risk of T2 DM with DN.
作者 林新伟 杨阳
出处 《解放军医学杂志》 CAS CSCD 北大核心 2014年第11期898-901,共4页 Medical Journal of Chinese People's Liberation Army
关键词 糖尿病肾病 HSP70热休克蛋白质类 多态性 单核苷酸 diabetic nephropathies HSP70 heat-shock proteins Gene polymorphism
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