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卵巢上皮性肿瘤组织中碳酸酐酶Ⅸ的表达变化及意义 被引量:3

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摘要 目的观察卵巢上皮性肿瘤组织中碳酸酐酶Ⅸ(CAⅨ)的表达变化,并探讨其临床意义。方法采用免疫组化法对45例卵巢上皮性良性肿瘤、50例交界性肿瘤、61例卵巢癌组织中的CAⅨ进行检测。结果 CAⅨ在卵巢上皮性良性肿瘤、交界性肿瘤、卵巢癌组织中的阳性表达率分别为17.8%、36.0%、59.0%;卵巢癌与卵巢上皮性良性肿瘤相比,P<0.01;卵巢癌与交界性肿瘤相比,P<0.05;卵巢上皮性良性肿瘤与交界性肿瘤相比,P<0.05。CAⅨ的表达与卵巢癌的分化程度、淋巴结转移及临床分期有关(P均<0.05)。结论 CAⅨ在卵巢上皮性良性肿瘤、交界性肿瘤、卵巢癌组织中的阳性表达率逐渐升高,其可能参与了卵巢癌的发生、发展,并与卵巢癌的浸润、转移密切相关。检测CAⅨ有助于卵巢癌的诊断及预后判断。
出处 《山东医药》 CAS 2014年第43期74-75,共2页 Shandong Medical Journal
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