期刊文献+

血清同型半胱氨酸、血脂水平与冠心病关系研究 被引量:4

Relationship between homocysteine,blood lipid and coronary heart disease
下载PDF
导出
摘要 目的:探讨血清同型半胱氨酸(Hcy)及血脂水平与冠状动脉粥样硬化性心脏病(CHD)之间的关系。方法选择2013年1月至2014年4月在该院心内科住院的204例CHD患者为CHD组,其中中青年(36~<60岁)87例,老年(60~88岁)117例;同时选择在该院健康体检者122例为对照组,其中中青年(39~<60岁)52例,老年(60~83岁)70例。分别检测两组受试者血清Hcy水平,三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白AⅠ(apoAⅠ)、apoB、脂蛋白(a)[Lp(a)]水平,并进行比较与分析。结果两组老年Hcy水平显著高于中青年,且CHD组不同年龄的Hcy水平显著高于对照组,差异均有统计学意义(P<0.05);CHD组患者的Hcy、TG、Lp(a)水平显著高于对照组,apo AⅠ水平显著低于对照组,差异均有统计学意义(P<0.05),而两组之间TC、HDL-C、LDL-C、apoB水平比较,差异均无统计学意义(P>0.05)。结论 Hcy水平与年龄有关,是CHD的独立危险因子,其与血脂指标联合检测,对CHD患者的诊断、治疗及预后具有重要临床意义。 Objective To explore the relationship between levels of serum homocysteine (Hcy),blood lipid and coronary heart disease (CHD). Methods A total of 204 patients with coronary heart disease patients was selceted as the CHD group ,in-cluding 87 young and middle-aged patients(36-<60 years old) and 117 aged patients(60-88 years old),meanwhile,another 122 healthy people were deem as the control group including 52 youths (39-60 years old) and the middle-aged and 70 aged people (60-83 years old), the levels of Hcy TG,TC,HDL-C,LDL-C,apoAⅠ,apoB,Lp(a) of the two groups were detected and com-pared. Results Hcy levels of the two aged groups were significantly higher than that of the young and middle-aged. Hcy level in different ages in CHD group was significantly higher than that of the control group (P<0.05). Hcy,TG,Lp(a) were significantly high-er than those of the control group,while apoAⅠwas significantly lower than the control group (P<0.05). TC,HDL-C,LDL-C and apo B levels between the two groups had no significant difference(P>0.05). Conclusions Hcy level is associated with age,who is one of independent risk factors for coronary heart disease;meanwhile,the combined inspection of CHD and blood lipids is bene-fit for the diagnosis,treatment and prognosis of great clinical significance.
作者 胡晓美 王菲
出处 《现代医药卫生》 2014年第23期3548-3549,3551,共3页 Journal of Modern Medicine & Health
关键词 脂类/血液 冠心病 胆固醇 脂蛋白类 HDL 同型半胱氨酸 Lipids/blood Coronary disease Cholesterol Lipoproteins,HDL Homocysteine
  • 相关文献

参考文献16

二级参考文献89

共引文献127

同被引文献55

  • 1李英莲.糖代谢异常和臂踝脉搏波传导速度与血浆同型半胱氨酸的关系[J].青海医药杂志,2012,42(5):9-11. 被引量:1
  • 2石胜,陈健勇,黄华兴,卢岑.血浆同型半胱氨酸水平与肝硬化严重程度的相关性研究[J].实用医学杂志,2004,20(5):530-531. 被引量:19
  • 3李昌棣,叶怀莲,闵姜勇,邓新,毛亚平.高胱氨酸血症与冠心病关系的临床观察及动物实验[J].中华老年医学杂志,1994,13(1):49-50. 被引量:20
  • 4陈健,张陆,陈柏楠.同型半胱氨酸致动脉粥样硬化机制的研究进展[C].中华中医药学会周围血管病分会学术大会论文集(二).北京:中华中医药学会,2009.
  • 5De Bree A, Verschuren WM, Kromhout D, et al. Homo- cysteine determinants and the evidence to what extent ho- mocysteine determines the risk of coronary heart disease [J]. Pharmaeol Rev, 2002,54 (4) : 599-618.
  • 6Yagura C, Takamura N, Kadota K, et al. Evaluation of cardiovascular risk factors and related clinical markers in healthy young Japanese adults[J]. Clin Chem Lab Med, 2007,45(2) :220-225.
  • 7Himmatrao SB,Parag HB, Pramodini HB. Homocysteine: of- ter neglected but common culprit of coronary heart disease [J]. J Cardiovas Dis Res,2014,5 :40-42.
  • 8Mohd Hanafiah K, Groeger J, Flaxman AD ,et al. Global epidemiology of hepatitis C virus infection :new estimates of age-specific antibody to HCV seroprevalence[J]. Hepatology, 2013,57 ( 4 ) : 1333 - 1342.
  • 9Mustafa M, Hussain S,Qureshi S,et al. Study of the effect of antiviral therapy on homocysteinemia in hepatitis C virus- infected patients[J]. BMC Gastroen- terol,2012,12 : 117.
  • 10Schroecksnadel K, Frick B, Winkler C, et al. Aspirin downregulates homo- eysteine formation in stimulated human peripheral blood mononuclear cells[J]. Stand J Immunol, 2005,62 (2) : 155-160.

引证文献4

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部