高血压病患者尿微量白蛋白与血管内皮功能及氧化应激的关系被引量：2

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摘要目的探讨高血压病患者尿微量白蛋白(urinary microalbumin,UMA)与血管内皮功能及氧化应激的关系。方法选择2010年2月-2012年6月期间我院收治的110例高血压病患者,以尿微量白蛋白量水平将110例高血压病患者分为MA组(≥30mg/24h)、NMA组(<30mg/24h)。分别测定患者血清中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、氧化低密度脂蛋白抗体(OLAb)滴度、血管性血友病因子(vWF)、血管内皮素-1(ET-1)。结果 MA组SOD、GSH-Px活性较NMA组下降,而OLAb滴度较NMA增高(P<0.01);MA组血浆的vWF、ET-1水平明显高于NMA组的(P<0.05);尿微量白蛋白与SOD、GSHPx、vWF、ET-1负相关,与OLA b滴度呈正相关,相关系数分别为-0.623、-0.512、-0.464、-0.327、0.786(P<0.01)。结论高血压病患者若检测尿微量白蛋白结果呈阳性,则提示患者血管内皮功能存在严重损伤,以及氧化应激状态,上述两种状况易导致高血压患者早期肾脏损伤。

作者赵静

机构地区河北省保定市第二中心医院心内

出处《宁夏医科大学学报》 2014年第7期808-810,共3页 Journal of Ningxia Medical University

关键词高血压病尿微量白蛋白氧化应激血管内皮功能

分类号 R544.1 [医药卫生—心血管疾病]

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