摘要
目的探讨抗菌药物专项整治前后病原菌对临床常见抗菌药物耐药性变迁,为进一步促进临床合理使用抗菌药物提供参考。方法收集2010-2012年医院抗菌药物专项整治前后临床分离3 805株病原菌对常用抗菌药物耐药率资料,进行对比分析,数据采用SPSS19.0软件进行分析。结果抗菌药物专项整治前医院共分离病原菌3 805株,其中革兰阳性菌688株占18.1%,革兰阴性菌2 754株占72.4%;整治后共分离病原菌5 902株,其中革兰阳性菌1428株占24.2%,革兰阴性菌4 172株占70.7%;绝大部分病原菌的耐药率在抗菌药物专项整治后均有所下降,铜绿假单胞菌的耐药率下降趋势尤为显著(P<0.01)。结论严格抗菌药物管理,控制抗菌药物的使用,使细菌耐药率下降,表明医院专项整治活动取得一定效果,临床抗菌药物合理使用水平逐渐提高。
OBJECTIVE To investigate the changes in bacterial resistance before and after the special rectification of antimicrobial drugs so as to provide reference for further promotion of the reasonable use of antimicrobial drugs . METHODS The data on the antibiotic resistance rate of the bacteria isolated from 3805 clinical samples before and after the special rectification of antimicrobial drugs in our hospital were collected and compared .Data were ana‐lyzed with the software SPSS19 .0 .RESULTS Before and after the special rectification of antimicrobial drugs ,a to‐tal of 3805 and 5902 pathogenic strains were clinically isolated in our hospital ,respectively ,688 （18 .1% ） and 1428 （24 .2% ） of which were gram‐positive bacteria ,2754 （72 .4% ） and 4172 （70 .7% ） of which were gram‐neg‐ative bacteria ,respectively .The resistance rate of most pathogenic bacteria strains were reduced after the special rectification .Especially , Pseudomonas aeruginosa were significantly decreased （P〈0 .01） .CONCLUSION The resistance rate of bacteria was declined due to strengthening the management and regulating the use of antibacterial drugs ,indicating that achievements were made in our hospital after the special rectification of antibacterial drug and the rational use of antibiotics was significantly improved gradually .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第23期5836-5838,共3页
Chinese Journal of Nosocomiology
基金
四川省卫生厅科研基金资助项目(110611)
关键词
抗菌药物
专项整治
耐药率
合理使用
Antibacterial drug
Special rectification
Resistance rate
Rational use
