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埃索美拉唑四联1周疗法根除幽门螺杆菌临床研究

Clinical research of esomeprazole 1 week quadruple therapy in the eradication of helicobacter pylori
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摘要 目的探讨埃索美拉唑四联1周疗法根除幽门螺杆菌(HP)的临床疗效。方法幽门螺杆菌阳性的胃溃疡、十二指肠溃疡患者80例,随机分为观察组和对照组,各40例,观察组给予埃索美拉唑四联1周疗法,对照组给予埃索美拉唑三联1周疗法,停药1个月后比较两组患者幽门螺杆菌清除率及溃疡愈合率。结果观察组HP根除率95.0%(38/40)显著高于对照组82.5%(33/40)(P<0.05);观察组与对照组溃疡愈合率分别为92.5%、90.0%,两者差异无统计学意义(P>0.05)。结论埃索美拉唑四联1周疗法在根除幽门螺杆菌时临床效果显著,可广泛推广。 Objective To explore the clinical effect of esomeprazole 1 week quadruple therapy in the eradication of helicobacter pylori (HP). Methods A total of 80 patients with HP-positive gastric ulcer and duodenal ulcer were randomly divided into observation group and control group, and each group contained 40 cases. The observation group received esomeprazole 1 week quadruple therapy, and the control group received esomeprazole 1 week triple therapy. Comparison was made on the HP eradication rate and ulcer healing rate between the two groups after 1 month of drug withdrawal. Results HP eradication rate of the observation group was 95.0% (38/40), which was obviously higher than 82.5% (33/40) of the control group (P〈0.05). The ulcer healing rates of the observation group and the control group were 92.5%and 90.0%respectively, and the difference had no statistical significance (P〉0.05). Conclusion Esomeprazole 1 week quadruple therapy in the eradication of HP has significant effect, and it can be widely promoted.
出处 《中国现代药物应用》 2014年第22期19-20,共2页 Chinese Journal of Modern Drug Application
关键词 埃索美拉唑 幽门螺杆菌 临床疗效 Esomeprazole Helicobacter pylori Clinical effect
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  • 1陈东燕,孙艳荪,乔珊,吴子刚.CYP2C19基因多态性对幽门螺杆菌感染酸相关性疾病治愈率的影响[J].实用医学杂志,2006,22(19):2324-2326. 被引量:7
  • 2成虹,胡伏莲,谢勇,胡品津,王吉耀,吕农华,张建中,张桂英,周曾芬,吴克利,张玲霞,彭孝伟,戴宁,唐国都,姜葵,李岩,侯晓华,白文元,王明春,叶红军,刘玉兰,许乐.中国幽门螺杆菌耐药状况以及耐药对治疗的影响—全国多中心临床研究[J].胃肠病学,2007,12(9):525-530. 被引量:518
  • 3Barbara G, Joanna W, Teresa S, et al. Effect of CYP2CI9 and MDRI polymnrphisms on cure rate in patients with acid- related disorders with Helicobacler pylori infection [J]. Eur J Clin Pharmacol, 2005,61 ( 5-6 ) : 375-379.
  • 4Oh J H, Dong M S, Choi M G, et al. Effects of CYP2CI9 anti MDRI genotype on the eradication rate of Helicobacler pylari infection by triple therapy with pantoprazole, amoxycillin and elarithromycin [J]. J Gastroenterol Hepatol, 2009, 24(2) : 294-298.
  • 5Fuccio L,Eusebi LH,Zagari RM,et al.Helicohacter pylofieradication treatment reduces but does not abolish the risk ofgastric callcer [J].Am J Gastmememl,2009,104(12):3101-3102.
  • 6Kandulski A,Selgrad M,Malfertheiner P. Helicobacter pylori infection:a clinical overview[J].Digestive and Liver Disease,2008,(08):619-626.doi:10.1016/j.dld.2008.02.026.
  • 7Dai WQ,Zhou YQ,Xu L. The eradicating Helicobacter pylori infection in duodenal ulcer patients by three short-term triple therapies in China:a multicenter clinical comparative study[J].Hepato-Gastroenterology,2012,(113):296-299.
  • 8Wu W,Yang Y,Sun G. Recent insights into antibiotic resistance in Helicobacter pylori eradication[J].Gastroenterology Research and Practice,2012,(2012):723183-723191.
  • 9Cho DK,Park SY,Kee WJ. The trend of eradication rate of Helicobacter pylori infection and clinical factors that affect the eradication of first-line therapy[J].Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi,2010,(06):368-375.
  • 10Uygun A,Kadayifci A,Safali M. The efficacy of bismuth containing quadruple therapy as a first-line treatment option for Helicobacter pylori[J].Journal of Digestive Diseases,2007,(04):211-215.doi:10.1111/j.1751-2980.2007.00308.x.

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