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抑郁症的神经炎症机制研究现状 被引量：7

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摘要 抑郁症是一种常见的精神疾患,全球范围内共有超过3.5亿人患病,分布于各个年龄组.抑郁症的发病率及致残率较高,目前我国抑郁症疾病负担在所有疾病中排列第2位,预计至2020年抑郁症将成为第2位危害人类健康的疾病.世界卫生组织预测至2030年,抑郁症将与冠心病、恶性肿瘤位居全球疾病负担前3位.抑郁症的发病机制不明,存在多种假说,其中包括脑内单胺类神经递质5-HT、去甲肾上腺素及多巴胺水平降低;下丘脑-垂体-肾上腺（hypothalamic-pituitary-adrenal,HPA）轴调节异常;脑源性神经营养因子（brain-derived neurotrophic factor,BDNF）等神经营养因子水平下降以及神经炎症假说等.
作者 苏凡 张志珺
机构地区 东南大学医学院 东南大学附属中大医院神经内科
出处 《中华精神科杂志》 CAS CSCD 北大核心 2014年第6期378-381,共4页 Chinese Journal of Psychiatry
关键词 脑内单胺类神经递质 抑郁症 炎症机制 脑源性神经营养因子 下丘脑-垂体-肾上腺 疾病负担 世界卫生组织 去甲肾上腺素
分类号 R749.4 [医药卫生—神经病学与精神病学]
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参考文献27

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共引文献66

同被引文献91

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  • 3杨玉荣,佘锐萍,梁宏德.Toll-NF-κB信号途径及其介导的功能[J].细胞生物学杂志,2007,29(4):483-486. 被引量：43
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二级引证文献71

中华精神科杂志
2014年 第6期

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