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高血压性肾损害患者血清HCY、尿液β_2-MG水平变化及意义 被引量:7

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摘要 目的观察高血压性肾损害患者血清同型半胱氨酸(HCY)和尿液β2微球蛋白(β2-MG)水平变化,探讨二者在高血压性肾损害诊断中的临床应用价值。方法选择高血压性肾损害患者79例为观察组,健康对照者70例为对照组,分别检测其血清HCY和晨尿β2-MG水平。计算观察组血清HCY和尿β2-MG阳性率。结果观察组男性患者血清HCY水平为(19.8±14.9)μmmol/L、女性为(16.9±8.7)μmmol/L,均高于对照组男性的(9.6±8.0)μmmol/L和女性的(8.6±6.2)μmmol/L,P均<0.05。观察组男性患者尿β2-MG水平为(0.76±0.38)mg/L、女性为(0.73±0.44)mg/L,均高于对照组男性的(0.42±0.26)mg/L和女性的(0.34±0.12)mg/L,P均<0.05。观察组患者血清HCY阳性率男性84.2%、女性72.7%,β2-MG阳性率男性93.0%,女性为100%。结论高血压性肾损害患者血清HCY和尿β2-MG升高。检测血清HCY和尿β2-MG水平有助于诊断高血压性肾损害。
出处 《山东医药》 CAS 2014年第34期82-83,共2页 Shandong Medical Journal
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  • 1邵耀明,吴国荣,倪芳颖.血清高半胱氨酸水平、尿微量白蛋白联合检测在糖尿病肾病中的临床意义[J].中国血液流变学杂志,2008,18(2). 被引量:28
  • 2魏有仁,侯林浦,王玫,湛玉良,朱立华.尿中微量白蛋白的测定及应用[J].生物化学与生物物理进展,1995,22(2):169-173. 被引量:84
  • 3Collins A J, Foley RN, Chavers B, et al. United States Renal Data System 2011 Annual Data Report:Atlas of chronic kidney disease & end-stage renal disease in the United States[ J]. AM J Kidney Dis, 2012,59(1 Suppl 1) :A7 ,el -420.
  • 4ERA-EDTA Registry. ERA-EDTA Registry 2003 Annual Report [ J ]. Amsterdam, Academic Medical Centre,2005.
  • 5Li LS, Liu ZH. Epidemiologic data of renal diseases from a single u- nit in China: analysis based on 13 519 renal biopsies [ J]. Kidney int,2004,66 (3) :920 - 923.
  • 6Zucchelli P, Zuccal0. A. Recent data on hypertension and progressive renal disease[ J l. J Hum Hypertens, 1996,10 (10) :679 -682.
  • 7Kincaid-Smith P. Hypothesis:obesity and the insulin resistance syn- drome play a major role in end-stage renal failure attributed to hy- pertension and labelled ' hypertensive nephrosclerosis' [ J ]. J Hy- pertens,2004,22(6) :1051 - 1055.
  • 8Freedman BI, Hicks PJ, Bostrom MA, et al. Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly asso- ciated with end-stage renal disease historically attributed to hyper- tension in African Americans[ J ]. Kidney Int ,2009,75 (7) :736 - 745.
  • 9Lipkowitz MS, Freedman BI, Langefeld CD, et al. Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in Mrican Americans[ J]. Kidney Int,2012,25.
  • 10Caetano ER, Zatz R, Saldanha LB, et al. Hypertensive nephrosclero- sis as a relevant cause of chronic renal failure [ J 1. Hypertension, 2001,38(2) :171 - 176.

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  • 1刘力生.中国高血压防治指南2010[J].中国医学前沿杂志(电子版),2011,3(5):42-93. 被引量:1225
  • 2中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华心血管病杂志,2011,390:579-616.
  • 3中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科分学会,突发性聋的诊断和指南(2015).中华耳鼻咽喉头颈外科杂志,2015,50:443.
  • 4Marcucci R, Alessandrello LA, Cellai AP, et al. Cardiovascular and thrombophilic risk factors for idiopathic sudden sensorineural hearing loss. Thromb Haemost ,2005,3 : 929-934.
  • 5范红星,李锋.老年H型高血压患者血同型半胱氨酸与24h微量蛋白尿及尿B2微球蛋白相关性研究.医学信息,2015,28:35-36.
  • 6Henning BF, Riezler R, Tepel M, et al. Evidence of altered homocys- teine metabolism in chronic renal failure. Nephron, 1999,83:314-322.
  • 7Schaub S, Wilkins JA, Antonovici M, et al. Proteomic-based identifica- tion of cleaved, urinary beta2-microglobulin as a potential marker for a- cute tubular injury in renal allografts. American Journal of Transplanta- tion ,2005,5:729-738.
  • 8李颖,高志洪,沈玉琴.血清胱抑素c对高血压早期肾损害的诊断价值分析[J].医药前沿,2014,3:223.
  • 9Tarif N, Alwakeel JS, Mitwalli AH, et al. Serum Cystatin C as a marker of renal function in patients with acute renal failure [J]. Saudi Kidney Dis Transpl, 2008,19 .. 918.
  • 10陈松岳,许敏达,赵智翔.老年突发性耳聋患者血浆同型半胱氨酸和肾上腺髓质素含量变化的意义[J].中华老年医学杂志,2009,28(5):405-407. 被引量:5

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