期刊文献+

桥本甲状腺炎与甲状腺乳头状癌发病的相关性探讨 被引量:3

下载PDF
导出
摘要 目的分析桥本甲状腺炎(HT)与甲状腺乳头状癌(PTC)发病的相关性。方法甲状腺结节手术患者2 083例中,PTC 722例,其中伴HT 122例(HT-PTC组),不伴HT 600例(非HT-PTC组);良性结节1 337例,其中伴HT 138例(HT良性组),不伴HT 1 199例(非HT良性组),对各组临床及病理资料进行分析。结果伴HT者PTC发生率高于不伴HT者(P<0.01);HT-PTC组与非HT-PTC组相比,女性比例更高(P<0.01),发病年龄更小(P<0.05),Tg Ab、TPOAb阳性率更高(P均<0.01)。非HT-PTC组与非HT良性组比较,发病年龄更小(P<0.01),TSH水平及Tg Ab、TPOAb阳性率更高(P均<0.01)。HT-PTC组与非HT-PTC组肿瘤直径、病灶数、淋巴结转移、TNM分期等均无统计学差异。结论 HT是PTC发病的危险因素,伴HT的PTC患者发病年龄更小,女性所占比例更高。
出处 《山东医药》 CAS 2014年第38期51-53,共3页 Shandong Medical Journal
基金 山东省交通科技创新计划(2012Y55-3)
  • 相关文献

参考文献3

二级参考文献35

  • 1翟凤英,何宇纳,马冠生,李艳平,王志宏,胡以松,赵丽云,崔朝辉,李园,杨晓光.中国城乡居民食物消费现状及变化趋势[J].中华流行病学杂志,2005,26(7):485-488. 被引量:206
  • 2高明,李小龙,于洋,孙保存,李树玲,徐文贵.甲状腺癌的临床病理及PET-CT的诊断价值[J].中华耳鼻咽喉头颈外科杂志,2006,41(6):419-424. 被引量:25
  • 3Ryska A. Angiogenesis in tumors. Part I. Its role in the determination of biological characteristics of tumors; factors controlling the onset and development of angiogenesis. Cesk Patol, 2000, 36: 26-31.
  • 4Hoffmann S, HoPoauer LC, Scharrenbach V, et al. Thyrotropin (TSH) -induced production of vascular endothelial growth factor in thyroid cancer cells in vitro : evaluation of TSH signal transduetion and of angiogenesis-stimulating growth factors. J Clin Endocrinol Metab, 2004, 89: 6139-6145.
  • 5Gerard AC, Daumerie C, Mestdagh C, et al. Correlation between the loss of thyroglobulin iodination and the expression of thyroid- specific proteins involved in iodine metabolism in thyroid carcinomas. J Clin Endocrinol Metab, 2003, 88 : 4977-4983.
  • 6Kim H, Lee TH, Park ES, et al. Role of peroxiredoxins in regulating intracellular hydrogen peroxide and hydrogen peroxide- induced apoptosis in thyroid cells. J Biol Chem, 2000, 275: 18266-18270.
  • 7Kim HJ, Chae HZ, Kim YJ, et al. Preferential elevation of Prx I and Trx expression in lung cancer cells following hypoxia and in human lung cancer tissues. Cell Biol Toxicol, 2003, 19: 285-298.
  • 8Welsh SJ, Bellamy WT, Briehl MM, et al. The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis. Cancer Res, 2002, 62: 5089-5095.
  • 9Park JH, Kim YS, Lee HL, et al. Expression of peroxiredoxin and thioredoxin in human lung cancer and paired normal lung. Respirology, 2006, 11 : 269-275.
  • 10Biaglow JE, Miller RA. The thioredoxin reductase/thioredoxin system: novel redox targets for cancer therapy. Cancer Biol Ther, 2005, 4: 6-13.

共引文献92

同被引文献24

引证文献3

二级引证文献36

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部