摘要
目的 探讨化疗联合树突状细胞-细胞因子诱导的杀伤细胞（DC-CIK）生物治疗在非小细胞肺癌（NSCLC）中的治疗价值,并且通过多层CT肺灌注成像的方法评价治疗效果的可行性.方法 选取经确诊的NSCLC患者30例（男性15例、女性15例）,平均年龄（70.5±2.1）岁,将患者按照随机数字表分成对照组（n=15）和治疗组（n=15）.对照组选用奥沙利铂＋多烯紫杉醇的化疗方案,治疗组在此基础上增加DC-CIK生物治疗,两组治疗前、后均进行多层螺旋CT肺灌注成像.比较两组的临床治疗有效率（RR）和临床获益率（CBR）,比较两组治疗前、后的CT灌注指标,包括血流量（BF）、血容量（BV）、表面通透性（PS）、达峰时间（TP）和平均通过时间（MTT）.结果 对照组和治疗组的总RR为70.0％,总CBR为96.7％.其中,对照组的RR为46.7％、CBR为93.3％;治疗组的RR为93.3％、CBR为100％.在RR方面,治疗组与对照组相比差异有统计学意义（χ^2=9.210,P＜0.05）.对照组治疗后的CT灌注指标较治疗前变化不具有统计学意义,治疗组治疗后的CT灌注指标较治疗前差异有统计学意义,表现为BF、BV、PS、TP均减低,MTT延长,治疗组的CT灌注指标与对照组比较差异有统计学意义.结论 联合DC-CIK治疗NSCLC比单纯化疗可以显著提高RR和CBR,并且多层螺旋CT灌注成像可以有效评价治疗效果.
Objective To evaluate the value of chemotherapy combined with dendritic cell-cytokine induced killer （DC-CIK） bio-treatment in the treatmeat of non-small cell lung cancer （NSCLC）and to estimate the therapeutic results by multislice spiral CT lung perfusion.Methods 30 cases of NSCLC patients who aged between 60 to 81 were collected,half male and half female,with an average age of 70.5 ±2.1.The patients were randomly divided into the treatment （n=15） and control groups （n=15）.The control group was treated with oxaliplatin ＋ docetaxel chemotherapy,and the treatment group increased DC-CIK biological treatment on this basis.Multislice spiral CT lung perfusion was performed in all of the patients before and after treatment.The clinical response rate （RR）and clinical benefit rate （CBR）were compared between the two groups,and the CT perfusion indices were compared before and after treatment,including blood flow （B F）,blood volume （BV）,permeability surface （PS）,peak time （TP） and mean transit time（MTT）.Results The total RR and CBR of the two groups were 70.0％ and 96.7％.The RR and CBR in treatment group and control group were 46.7％,93.3％ and 93.3％,100％ respectively.Their differences had great statistical significance in RR between two groups （χ^2=9.210,P＜0.05）.No significant difference could be observed on the CT perfusion indices before and after treatment in the control group.On the contrary,there were significant changes before and after treatment in the treatment group,which expressed as BF,BV,PS,TP were decreased and MTT was prolonged.There were significant differences between the two groups in CT perfusion indices after treatment.Conclusion Chemotherapy combined with DC-CIK treatment can significantly improve the RR and CBR of non-small cell lung cancer than chemotherapy alone,and multi-slice spiral CT perfusion can effectively evaluate the therapeutic effect.
出处
《国际放射医学核医学杂志》
2014年第6期377-380,391,共5页
International Journal of Radiation Medicine and Nuclear Medicine
关键词
癌
非小细胞肺
生物疗法
药物疗法
CT灌注成像
疗效评价
Carcinoma, non-small-cell lung
Biological therapy
Drug therapy
CT perfusion imaging
Evaluation
