摘要
创面愈合是多个生物学功能相互作用的复杂过程,一旦创面形成,便触发多个生物学通路协同作用,例如血液凝固、炎性细胞浸润、多细胞群体迁移分化以及特异基因表达等,从而达到创面的最终愈合。对于成人,当皮肤损伤达到某种程度时,肉芽组织填充缺损,后逐渐纤维化形成瘢痕。与之形成鲜明对比的是早期胎儿创面的无瘢痕愈合,这种能力仅存在于产前发育期,一般在妊娠前24周。随着近年研究的不断深入,一些可能的影响因素逐渐被发现,但具体机制仍尚未明确。
Scarless healing is considered as the most ideal mode of wound repair.This ability generally exists in the early period of mammalian embryos,however it gradually turns to scar healing with the development of the embryos.This phenomenon is the result of the interaction of multiple biological functions,and the mechanism is still uncertain.This article deals with a systematical review of literature concerning the mechanism of scarless healing based on the recent experimental studies,hoping to provide evidence for the treatment of wounds to realize scarless healing in adult.
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2014年第6期499-502,共4页
Chinese Journal of Burns
基金
国家自然科学基金(30670571、30772258、81071560、81372074):山东省科技攻关项目(2009GG10002078)
关键词
瘢痕
伤口愈合
胎儿
无瘢痕愈合
Cicatrix
Wound healing
Fetus
Scarless healing