摘要
以4-氯甲基苯乙烯为起始原料,与三苯基膦生成季鏻盐(1)后,再在碱性(KOBut)条件下与苯甲醛衍生物(2a^2c)进行固相研磨Wittig反应,合成了3种二苯乙烯类化合物(3a^3c),其结构经1H NMR和IR确证。较佳的Wittig反应条件为:1 30 mmol,n(1)∶n(2)∶n(KOBut)=1.0∶1.2∶1.4,于70℃反应1 h,3a^3c的收率分别为75.0%,81.3%和85.0%。
Three stilbene compounds（ 3a ~ 3c） were synthesized in alkaline condition（ KOBu^t） by the solid phase grinding Wittig reaction of benzaldehyde derivatives（ 2a ~ 2c） with quaternary phosphonium salt（ 1） which was prepared by reaction of 4-chloromethyl styrene with triphenylphosphine.The structures were confirmed by^1 H NMR and IR. The optimum Wittig reaction conditions at 70 ℃for 1 h were as follows： 1 30 mmol,n（ 1） ∶ n（ 2） ∶ n（ KOBu^t） = 1. 0 ∶ 1. 2 ∶ 1. 4. The yield of 3a ~3c were 75. 0%,81. 3% and 85. 0%,respectively.
出处
《合成化学》
CAS
CSCD
2015年第1期77-79,82,共4页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(21103151)
