摘要
目的：探讨阿奇霉素联合维生素D治疗儿童哮喘的临床疗效。方法：选取儿童支气管哮喘患者90例,随机分为常规治疗组（A组）、阿奇霉素＋常规治疗组（B组）和阿奇霉素联合维生素D＋常规治疗组（C组）。所有患儿治疗前后均测定血清中白细胞介素（IL）-2、IL-17浓度,比较3组患儿治疗前后血液指标变化、症状体征好转时间及住院时间。结果：3组患儿治疗前血清IL-2和IL-17水平差异无统计学意义（P〉0.05）;治疗后3组患儿血清IL-2水平均较治疗前升高、IL-17水平降低（P〈0.01）,其中C组改变更为明显（P〈0.05-P〈0.01）;C组均较A组、B组症状体征好转时间短、住院时间缩短（P〈0.05-P〈0.01）。结论：阿奇霉素联合维生素D可以改善患儿气道炎症反应,提高机体抵抗力,改善患儿临床治疗疗效。
Objective： To investigate the clinical efficacy of azithromycin combined with vitamin D in the treatment of asthma of children. Methods： Ninety children with bronchial asthma were randomly divided into the conventional therapy group（ group A）,Azithromycin group（ group B） and azithromycin combined with vitamin D group（ group C）. The concentrations of serum interleukin（ IL）-2 and IL-17 in all patients were measured before and after the treatment. The blood parameters,the time of symptoms and signs improvement and hospital stays between 3 groups were compared before and after the treatment. Results： The differences of serum IL-2and IL-17 levels between 3 groups before treatment were not statistically significant（ P〉0. 05）. After the treatment,the levels of serum IL-2 and IL-17 in 3 groups increased and decreased,respectively（ P〈0. 01）,especially for group C（ P〈0. 05 to P〈0. 01）. The time of symptoms and signs improvement and hospital stays in group C were shorter than those in group A and B（ P〈0. 05 to P〈0. 01）.Conclusions： The treatment of azithromycin combined with vitamin D can improve the airway inflammation,body＇ s resistance and clinical efficacy in children.
出处
《蚌埠医学院学报》
CAS
2014年第11期1534-1536,共3页
Journal of Bengbu Medical College
