摘要
以L-苯丙氨酸为原料,经甲酯化反应制得中间体丙谷胺酸甲酯盐酸盐(1);以三乙胺为缚酸剂,1经固体光气活化制得苯丙氨酸异氰酸酯后,再分别与伯胺反应合成了4个苯丙氨酸脲类化合物(3a^3d),收率90.7%~94.2%,其结构经1H NMR,MS和X-衍射确证。
An intermediate,1-methoxy-1-oxo-3-phenylpropan-2-aminium chloride（ 1）,was prepared by methyl-esterification of L-phenylalanine. Four L-phenylalanine Derivatives in yield of 90. 7% -94. 2 were synthesized by activation of 1 via triphosgene,using triethylamine as the acid acceptor,and then reacted with primary amine. The structures were confirmed by^1 H NMR,MS and X-ray diffraction.
出处
《合成化学》
CAS
CSCD
北大核心
2014年第6期807-809,共3页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(21201087)
关键词
L-苯丙氨酸
脲类化合物
合成
工艺改进
L-phenylalanine
urea derivative
synthesis
process improvement
