摘要
目的探讨新疆哈萨克族与维吾尔族健康人群中心动脉压与肾功能的差异。方法于2009年8月—2010年2月在新疆塔城地区采取整群抽样方法,共抽取1 775例新疆哈萨克族自然人群,从中随机抽取符合纳排标准的528例哈萨克族健康人群;同期在新疆和田地区采取整群抽样方法,共抽取2 366例新疆维吾尔族自然人群,从中随机抽取符合纳排标准的530例维吾尔族健康人群作为本研究对象。对研究对象进行问卷调查、体格检查及血糖、血脂、血肌酐等指标的检测,采用Sphygmocor脉搏波分析仪检测中心动脉压,采用中国人校正的MDRD公式估算肾小球滤过率。结果新疆哈萨克族健康人群的中心动脉收缩压、脉压、增强压及中心动脉反射波增强指数均高于维吾尔族健康人群,肾小球滤过率低于维吾尔族健康人群,差异有统计学意义(P<0.05);哈萨克族女性的肾小球滤过率低于维吾尔族女性,差异有统计学意义(P<0.05)。相关分析显示:在维吾尔族和哈萨克族健康人群中,肾小球滤过率与中心动脉收缩压、脉压、增强压及反射波增强指数均呈负相关(P<0.05)。多元线性回归分析显示:年龄、增强压、反射波增强指数、肌酐是新疆哈萨克族健康人群肾小球滤过率的影响因素,年龄、增强压、反射波增强指数、肌酐是新疆维吾尔族健康人群肾小球滤过率的影响因素(P<0.05)。结论新疆哈萨克族健康人群的中心动脉压高于维吾尔族,存在民族差异性;哈萨克族女性肾小球滤过率较维吾尔族女性人群低;年龄、增强压、反射波增强指数及肌酐可能是新疆哈萨克族和维吾尔族人群肾小球滤过率的影响因素。
Objective To study the relationship between renal function and central aortic pressure among Kazak and Uygur population in Xinjiang.Methods Cluster random sampling method was used to select 1 775 Kazak natural population from Tacheng area and 2 366 Uygur natural population from Hetian area,Xinjiang between August,2009 and February,2010,from which 528 Kazak healthy and 530 Uygur healthy subjects meeting enter criterion were randomly sampled for this study.They received questionnaire investigation,physical examination,indexes detection including blood glucose,blood lipid and serum creatinine,central arterial systolic blood pressure measure by SphygmoCor pulse wave analyzer and GFR（ estimated glomerular filtration rate） calculation by the formula of Chinese- based MDRD（ Modification of Diet in Renal Disease）.Results Central aortic systolic pressure,pulse pressure,enhanced pressure and central aortic augmentation index were all significantly higher of Kazak population than those of Uygur populationand GFR was lower of Kazak population than that of Uygur population with significant difference（ P 0.05）; GFR was lower of Kazak women than that of Uygur women with significant difference（ P 0.05）.Correlation analysis showed that GFR was negatively correlated to central systolic blood pressure,pulse pressure,enhanced pressure and reflected wave augmentation index in both nationalities（ P 0.05）.Multiple linear regression analysis showed that age,enhanced pressure,the reflected wave augmentation index,creatinine were main factors affecting GFR in Kazak and Uygur healthy population.Conclusion Central aortic pressure of Kazak population was higher than that of Uygur population,with ethnic otherness.GFR of Kazak women was lower than that of Uygur women.Age,enhanced pressure,the reflected wave augmentation index and creatinine may be the influencing factors for GFR in Uygur and Kazak population,Xinjiang.
出处
《中国全科医学》
CAS
CSCD
北大核心
2014年第28期3331-3335,共5页
Chinese General Practice
基金
国家自然科学基金资助项目(30860296)
