摘要
目的探讨冻融囊胚移植、冻融卵裂期胚胎复苏后行囊胚移植的临床价值。方法回顾性分析2012年9月至2013年8月在该院生殖医学中心接受冻融胚胎移植治疗患者共518个周期的临床资料,按移植冻融胚胎类型分为3组。A组:冻融囊胚移植,共129个周期;B组:卵裂期胚胎复苏后行囊胚培养后移植,共123个周期;C组(对照):冻融卵裂胚移植,共266个周期。比较各组的临床结局及A、B两组间新鲜周期胚胎和冻融周期的囊胚形成率和取消率。结果 A、B组的生化妊娠率、临床妊娠率和胚胎种植率(70.5%、61.2%、42.3%;67.5%、58.2%、40.2%)显著高于C组(53.0%、42.5%、23.1%)(P<0.05);3组间流产率、异位妊娠率、多胎妊娠率差异无统计学意义(P>0.05)。新鲜周期第3天优质胚胎与冻融胚胎复苏后的囊胚形成率(62.5%vs.57.7%)差异无统计学意义(P>0.05),均显著高于新鲜周期第3天非优质胚胎的囊胚形成率(20.3%)(P<0.05)。结论冻融周期行囊胚移植可以获得较满意的临床结局;冻融卵裂期胚胎行囊胚培养后可获得较高的囊胚形成率和临床结局。
Objective To evaluate the clinical value of frozen-thawed blastocyst transfer and the blastocyst derived from frozen-thawed cleavage stage embryo transfer.Methods The data of 5 1 8 cycles in reproductive medicine center of the hospital from Sep-tember 2012 to August 2013 were analyzed retrospectively.According to the frozen-embryos type,all patients were divided into three groups,group A：frozen-thawed blastocyst transfer,129 cycles;group B：blastocysts derived from frozen-thawed cleavage stage embryos transfer,123 cycles;group C：frozen-thawed cleavage embryos transfer,266 cycles.The clinical outcomes of all groups were compared with each other,and the rates of blastocyst formation and cancellation were compared between group A and group B.Re-sults The rates of biochemical pregnancy,clinical pregnancy and embryo implantation in group A（70.5%,61.2%,42.3%）and group B（67.5%,58.2%,40.2%）were significantly higher than group C（53.0%,42.5%,23.1%）（P〈0.05）;there were no signif-icant differences in the rates of early abortion,ectopic pregnancy,multiple pregnancy among three groups（P〉0.05）;there were no significant differences in the blastocyst formation rates of the high quality cleavage embryos at D3 in fresh cycles and the frozen-thawed cleavage embryos（62.5%vs.57.7%）（P〉0.05）and those two groups were both significantly higher than the poor quality cleavage embryos at D3 in fresh cycles（20.3%）（P〈0.05）.Conclusion Blastocyst transfer in vitrified-thawed cycles could get rel-atively satisfactory clinical outcomes.There are higher blastocyst formation rate and better clinical outcomes of transfer blastocyst derived from frozen-thawed cleavage embryo.
出处
《重庆医学》
CAS
CSCD
北大核心
2014年第34期4610-4612,共3页
Chongqing medicine
关键词
囊胚培养
冻融胚胎
囊胚移植
临床妊娠率
种植率
blastocyst culture
frozen-thawed embryo
blastocyst transfer
clinical pregnancy rate
implantation rate
