摘要
目的研究尾加压素基因多态性与妊娠期糖尿病(GDM)的关系。方法应用聚合酶链式反应-限制性内切酶片段长度多态性(PCR-RFLP)技术检测GDM患者120例、正常孕妇100例的尾加压素基因rs228648位点。结果 GDM组患者尾加压素基因rs228648位点的A/A基因型频率为12.50%,均明显低于对照组的28.00%(P<0.05),A基因型频率为38.75%,均明显低于对照组的63.50%(P<0.05);GDM组患者尾加压素基因rs228648位点G基因型频率为61.25%,高于对照组的36.50%(P<0.05)。结论尾加压素基因rs228648位点多态性与GDM的遗传易感性有关联,rs228648位点的A型纯合子可能是GDM的重要保护因素。
Objective To study the relationship between polymorphism of urotensin gene and gestational diabetes mellitus（ GDM）. Methods The polymerase chain reaction-restriction enzyme fragment length polymorphism（ PCR-RFLP）technique was used to detect the locus rs228648 in urotensin gene among 120 patients with GDM and 100 normal pregnant women. Results The A / A genotype frequency of locus rs228648 in urotensin gene was 12. 50% in GDM patients,which was significantly lower than that（ 28. 00%） in the control group（ P〈0. 05）. And the A genotype frequency was 38. 75% in GDM patients,which was significantly lower than that（ 63. 50%） in the control group（ P〈0. 05）. The G genotype frequency of locus rs228648 in urotensin gene was 61. 25% in GDM patients,which was higher than that（ 36. 50%） in the control group（ P〈0.05）. Conclusion The polymorphism of locus rs228648 in urotensin gene correlates with the genetic susceptibility of GDM,the homozygote A of locus rs228648 may be an important protective factor for GDM.
出处
《广西医学》
CAS
2014年第11期1520-1521,共2页
Guangxi Medical Journal
基金
湖北省武汉市卫生局临床医学科研项目(WX10C01)
关键词
糖尿病
尾加压素基因
妊娠
多态性
相关性
Diabetes mellitus
Urotensin gene
Gestation
Polymorphism
Correlation
