摘要
目的：探讨精神分裂症患者血清心肌酶谱的变化及其临床意义。方法测定405例精神分裂症患者入院时血清心肌酶（ CK、CK－MB、LDH、α－HBDH）水平，于入院治疗4周后复查血清心肌酶水平，分析其与病情的关系，并与100例健康人（对照组）进行对照。结果精神分裂症阳性症状组患者治疗前血清CK、CK－MB、LDH、α－HBDH分别为（1286．52±714．38） U／L、（40．72±27．38） U／L、（143．06±33．24） U／L、（115．75±22．74）U／L，CK、CK－MB均高于对照组（t ＝10．35、9．29，均 P＜0．01）；治疗4周后 CK、CK－MB、LDH、α－HBDH分别为（98．13±38．75）U／L、（12．87±5．73）U／L、（125．43±25．74）U／L、（102．15±26．86）U／L，呈下降趋势，与对照组比较，差异均无统计学意义（均P＞0．05）。结论急性发作期精神分裂症患者血清心肌酶CK、CK－MB升高可能与病情有关。
Objective To investigate the changes of serum myocardial enzyme in schizophrenia patients spectrum and its clinical significance.Methods 405 patients with schizophrenia hospitalized patients serum myocar-dial enzyme （CK,CK-MB,LDH,α-HBDH level,） on admission and 4 weeks after treatment the serum myocardial enzyme level,analyze its relationship with the disease, and 100 healthy people （ control group） were compared. Results the positive symptoms of schizophrenia patients before treatment,serum CK,CK-MB,LDH,α-HBDH were （1 286.52 ±714.38） U/L,（40.72 ±27.38） U/L,（143.06 ±33.24） U/L,（115.75 ±22.74） U/L,CK,CK-MB were higher than those in the control group （t=10.35,9.29,all P〈0.01）;after 4 weeks of treatment,CK,CK-MB, LDH,α-HBDH were （98.13 ±38.75）U/L,（12.87 ±5.73）U/L,（125.43 ±25.74）U/L,（102.15 ±26.86）U/L, compared with the control group,the differences were not statistically significant（all P〉0.05）.Conclusion Serum myocardial enzyme CK and CK-MB increased level was related with diseasein the patients with acute exacerbation of schizophrenia.
出处
《中国基层医药》
CAS
2014年第24期3704-3705,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
精神分裂症
心肌酶
Schizophrenia
Cardiac enzymes
