摘要
目的:探讨解毒软肝片抗乙型肝炎肝纤维化的机制。方法:自胫静脉注射鸭乙肝病毒阳性血清,建立鸭乙型肝炎肝纤维化的动物模型,用解毒软肝片灌胃治疗,并以秋水仙碱作对照,治疗结束后检测动物血清肝纤维化相关指标。结果:1各组动物肝功能指标的变化:模型组动物较正常组血清白蛋白降低(P<0.05),球蛋白显著升高(P<0.01),A/G倒置(P<0.01),血清MDA显著升高(P<0.01)。解毒软肝片小剂量组能显著降低血清MDA水平(P<0.05);解毒软肝片大剂量组能显著降低球蛋白(P<0.05),升高白蛋白(P<0.01),恢复至正常水平,能显著降低血清MDA水平(P<0.01)。2肝纤维化指标改变情况:模型组动物较正常组血清肝纤维化指标PCⅢ、HA、LN和肝组织Hyp含量均明显升高(P<0.05);解毒软肝片大、小剂量组血清PCIII、HA、LN和肝组织Hyp含量较模型组均显著降低(P<0.01)。3光镜下各组动物肝纤维化分级情况比较:模型组较正常组有明显差别(P<0.01),解毒软肝片大剂量组与模型组比较有差别(P<0.05)。结论:解毒软肝片具有良好的抗肝纤维化作用。
Objective： To study the mechanism of protective effect of Jiedu Ruangan tablet on the liver fibrosis-induced by hepatitis B virus in duck. Methods： The animal models of liver fibrosis were established by injecting DHBV positive serum from cnemial vein and treated by Jiedu Ruangan tablet and colchicin, respectively. To detect levels of serum indices about liver fibrosis at the end of treatment. Results： Jiedu Ruangan tablet could improve the liver function of animal models significantly （ P 〈 0.05, P 〈 0.01 ） . Jiedu Ruangan tablet could improve levels of serum indices about liver＇fibrosis significantly, such as PC III, HA, LN and the content of Hyp in hepatic tissue （ P 〈 0. 01 ） . Jiedu Ruangan tablet could improve the grade information of liver fibrosis significantly （P 〈 0. 05 ） . Conclusion： Jiedu Ruangan tablet has better protective effect on the liver fibrosis induced by hepatitis B virus.
出处
《中西医结合肝病杂志》
CAS
2014年第6期354-356,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
关键词
解毒软肝片/药理作用
肝纤维化
动物模型
Jiedu Ruangan tablet/pharmacological effect
liver fibrosis
animal models
