摘要
美国甲状腺学会（ATA）制定的妊娠期甲状腺疾病的权威指南提出诊断亚临床甲状腺功能减退的2个标准：标准1依据妊娠期特异的血清TSH上限,标准2根据血清TSH＞2.5 mIU/L、FT4在正常范围.根据“妊娠早期妇女亚临床甲状腺功能减退的筛查和干预研究”的结果,标准2不适合我国的妊娠妇女.因为我国人群的血清TSH水平普遍升高.如果依据标准2诊断亚临床甲状腺功能减退,患病率高达27.8％,造成亚临床甲状腺功能减退的过度诊断和过度治疗.
Guidelines of the American Thyroid Association （ATA） proposed two diagnostic criteria for subclinical hypothyroidism during the first trimester of pregnancy：criterion 1 was based on the pregnancy-specific TSH reference range and criterion 2 on serum TSH＞2.5 mIU/L level with normal serum FT4.According to the results of the ＂Subclinical hypothyroidism during early pregnancy＂ study,author proposed that criterion 2 is not appropriate for Chinese pregnant women because the TSH concentration has become significantly higher in whole Chinese population.By using criterion 2,the prevalence may be as high as 27.8％,which may result in over-diagnosis and over treatment.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2014年第12期1039-1040,共2页
Chinese Journal of Endocrinology and Metabolism
