摘要
胰岛β细胞再生治疗是糖尿病治疗领域的热点.成年人的β细胞以极低的自我复制速率进行增殖,但在胰岛素抵抗状态下,β细胞能够获得显著的再生能力,因此,有关胰岛素抵抗如何诱导β细胞增生的研究具有极其重要的临床意义.研究表明,胰岛素抵抗通过肝脏分泌的Betatrophin促进了β细胞增生.笔者研究团队2014年7月于《Diabetes Care》在线发表论著“初诊2型糖尿病患者血清Betatrophin水平升高”,旨在揭示糖尿病与Betatrophin的关系.
Replenishing the insulin-producing β cell mass is considered to be a hot topic in the field of diabetes treatment.It has long been known that pancreatic β cells are generated primarily by self-duplication in adults.However,insulin resistance can induce dramatic compensatory β cell mass expansion in the pancreas.Therefore,it is of great value to investigate the etiology and pathogenesis of β cell proliferation under insulin resistance.The recent study has shown that betatrophin,a protein secreted by the liver,modulates β cell growth in response to insulin resistance.We published one article in Diabetes Care titled ＂ Increased circulating levels of betatrophin in newly diagnosed type 2 diabetic patients ＂ to elaborate the relationship between diabetes and betatrophin.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2014年第12期1041-1043,共3页
Chinese Journal of Endocrinology and Metabolism
基金
国家自然科学基金面上项目（81370965）
江苏省自然科学基金资助项目（BK2009208）
江苏省卫生厅国际交流支撑计划及面上科技项目（H201247）
