摘要
目的观察乙酰半胱氨酸联合泼尼松治疗特发性肺间质纤维化(IPF)患者的治疗效果。方法将45例IPF患者随机分为3组,泼尼松组15例(A组),每日(理想体质量)0.5mg/kg,口服4周,然后每日0.25mg/kg,口服8周,继之减量至每日0.125mg/kg口服;小剂量乙酰半胱氨酸组15例(B组),在上述泼尼松治疗基础上加用乙酰半胱氨酸200mg,每日3次;大剂量乙酰半胱氨酸组15例(C组),在上述泼尼松治疗基础上加用大剂量乙酰半胱氨酸600mg,每日3次;疗程6个月。观察治疗前后各组患者肺活量(VC)、6分钟步行试验(6MWT)距离变化,评价总体疗效。结果 3组治疗后VC、6MWT较治疗前均降低。C组疗效好于A组和B组(P<0.05)。C组VC、6MWT较其他治疗组下降缓慢(P<0.05)。结论大剂量乙酰半胱氨酸联合泼尼松能延缓特发性肺间质纤维化患者肺功能下降及6MWT距离的减少。
ABSTRACT：Objective To study the effects of acetylcysteine plus prednisone on idiopathic pulmonary fibrosis （IPF）patients.Methods Forty-five IPF patients were randomly divided into control group 15 cases （treated with prednisone therapy only,group A）,low doses of acetylcysteine plus prednisone group 15 cases （acetylcysteine 200 mg per time,3 times a day orally for 6 months,group B）and large doses of acetylcysteine plus prednisone group 15 cases （acetylcysteine 600 mg per time,3 times a day orally for 6 months,group C）.The change of clinical symptoms,vital capacity（VC）,6 minute walk test distance（6MWT）were observed.Results VC and 6MWT after treatment were significantly lower than before treatment in all three groups.The effects in group C were significantly better than those in group A and B（P 〈0.05）.Conclusion High dose acetylcysteine plus prednisone therapy delayed IPF in patients with reduced lung function and decreased in 6 MWT.
出处
《临床荟萃》
CAS
2015年第1期38-40,共3页
Clinical Focus
关键词
特发性肺纤维化
肺活量
乙酰半胱氨酸
idiopathic pulmonary fibrosis
vital capacity
acetylcysteine
