摘要
目的:了解婴幼儿尿路感染的病原菌分布及耐药情况,为临床合理选择抗生素提供参考。方法:回顾分析2011-2013年余姚市人民医院和余姚市第二人民医院收治的经尿培养阳性婴幼儿247例,分析病原菌分布及药敏试验结果。结果:247株病原菌中,革兰阴性菌145株,占58.7%;革兰阳性菌98株,占39.7%;真菌4株,占1.6%。尿培养检出菌前3位的病原菌分别为大肠埃希菌、屎肠球菌、肺炎克雷伯菌。大肠埃希菌对亚胺培南敏感率为100%,对厄他培南、头孢西丁、哌拉西林/他唑巴坦及阿米卡星的敏感率大于90%。屎肠球菌对利奈唑胺、替加环素的敏感率为100%,对万古霉素、莫西沙星敏感率大于95%。结论:婴幼儿尿路感染的主要病原菌是大肠埃希菌和屎肠球菌,其中屎肠球菌的耐药性呈上升趋势,临床应该根据药敏试验结果合理选择抗生素。
OBJECTIVE： To investigate pathogenic bacteria distribution and drug resistance of infant urinary tract infection, to provide reference for rational selection of antibiotics in the clinic. METHODS： Retrospective analysis was performed in 247 infants with positive urine culture in Yuyao Municipal Second People＇s Hospital and Yuyao Municipal People＇s Hospital during 2011-2013; pathogenic bacteria distribution and results of drug susceptibility test were analyzed. RESULTS： Among 247 strains of pathogen- ic bacteria, there were 145 strains of Gram negative bacteria （58.7%）, 98 strains of Gram positive bacteria （39.7%） and 4 strains of fungi （1.6 % ）. Top 3 pathogens bacteria were Escherichia coli, Enterococcus feces and Klebsiella pneumoniae. E. coli was sensi- tive to imipenem completely; sensitivity rates to ertapenem, cefoxitin, piperacillin/tazobactam and amikacin were greater than 90%. E. feces were sensitive to linezolid and tigecycline completely; sensitivity rates to vancomycin and moxifloxacin were greater than 95%. CONCLUSIONS： The main pathogenic bacteria of infant urinary tract infection are E. coli and E. faecium; the drug resis- tance of E. faecium is in a upward trend. Antibiotics should be chosen reasonably according to the results of drug sensitivity test.
出处
《中国药房》
CAS
北大核心
2015年第2期207-209,共3页
China Pharmacy
关键词
尿路感染
病原菌
药敏试验
婴幼儿
Urinary tract infection
Pathogenic bacteria
Drug susceptibility test
Infant
