摘要
目的:探讨体外受精-胚胎移植术后三胎妊娠减胎前后的妊娠结局。方法:回顾性分析2011年10月至2013年12月广州医科大学附属第三医院收治的辅助生殖受孕病例31例;比较三胎妊娠、减胎后的双胎妊娠、单胎妊娠的流产率、孕期并发症发生率及新生儿围产期结局。结果:三胎妊娠、经减胎后的双胎妊娠、单胎妊娠在孕产次、胎儿疾病、胎膜早破、重度子痫前期、妊娠期糖尿病、产后出血等方面比较差异无统计学意义(P>0.05),在新生儿出生孕周、出生体重、早产率、新生儿转NICU率、新生儿RDS方面比较,差异有统计学意义,减胎后的双胎、单胎分娩孕周延长[三胎、双胎、单胎妊娠分娩孕周分别为(37.3±1.9)、(35.2±0.9)、(32.6±2.3)周]、早产率下降(100%、100%、33.3%)、新生儿出生体重增加[(1 707±360.4)g、(2 066.1±307.5)g、(2 712.5±514.1)g]、新生儿并发症少(P<0.05)。结论:多胎妊娠减胎术治疗降低了早产风险及新生儿低出生体重发生率,改善了母胎结局,但减胎后的早中孕期流产率较高。
Objective To study the outcomes of selective reduction of triplet pregnancy by assisted reproductive technology. Methods The clinical data of 31 women who succeeded in conception by vitro fertilization- embryo transfer in the third affiliated hospital of Guangzhou Medical University were retrospectively investigated to analyze and compare the rates of abortion from triplet pregnancy, twin pregnancy and single pregnancy after selective reduction of triplet pregnancy, the incidence of pregnant complications, outcomes of perinatal period. Results There were no significant differences between triplet pregnancy and the twin and single pregnancy after selective reduction of triplet pregnancy in terms of pregnancy and parity time, fetal disease, premature ruptu] e of membrane, severe eclampsism, gestational diabetes and postpartum hemorrhage （P 〉 0.05）. There were significant differences in gestational weeks, birth weight, rate of premature birth, rate of neonatal transfer to NICU and neol Latal RDS： The gestational time in the triplet group longer than the groups of twin pregnancy and single pregnancy after selective reduction of triplet pregnancy （ P 〈 0.05 ）. （37.3 ±1.9） vs. （35.2± 0.9）, （32.6±2.3）, respectively）, the rate of premature birth dropped （100% vs. 100%, 33.3%, respectively）, the body weight was increased （1 707 ±360.4） g vs. （2 066.1 ± 307.5）g, （2 712.5± 514.1 ）g, respectively and the neonatal complication rate was reduced （P 〈 0.05）. Conclusion The selective reduction of multiple pregnancy may decrease the risk of premature birth and reduce the rate of lower body weight of neonates, improving the pregnancy outcomes, but the higher rate of abortion at the early or middle course of pregnancy after selective reduction is worth our attention.
出处
《实用医学杂志》
CAS
北大核心
2014年第24期3979-3982,共4页
The Journal of Practical Medicine
基金
广州市"2011"产科重点疾病协同创新中心(编号:13xt04)
妊娠合并急危重症早期干预和规范化治疗研究及示范(编号:2014SQ00268)
关键词
三胎妊娠
辅助生殖
减胎
妊娠结局
Triplet pregnancy
Assisted reproduction
Selective reduction of triplet pregnancy
Pregmmcy outcome
