摘要
目的探讨冰己抑瘤丸对胶质瘤患者化疗敏感性及P21、VEGF表达的影响。方法将90例确诊为神经脑胶质瘤的患者随机分为A组(冰己抑瘤丸+替莫唑胺)30例、B组(汉防己+替莫唑胺)30例、C组(安慰剂+替莫唑胺)30例。对比3组总有效率、化疗敏感率及毒副反应发生率。分析治疗前后3组P21、VEGF表达水平的变化。结果 A组总有效率、化疗敏感率高于B、C组(P<0.05),毒副反应发生率低于B、C组(P<0.05)。A组治疗后P21、VEGF表达水平显著低于B、C组(P<0.05)。结论冰己抑瘤丸可提高胶质瘤患者化疗敏感性及治疗效果,抑制P21、VEGF表达水平,促进患者预后。
Objective To investigate the effects of Bingji Yiliu pellet on chemotherapy sensitivity and P21,VEGF expression in patients with glioma. Methods 90 patients with nerve glioma were randomly divided into group A(30 cases,Bingji Yiliu pellet+temozolomide),group B(30 cases,tetrandrine+temozolomide),group C(30 cases,placebo+temozolomide).The total effective rate,chemotherapy sensitivity rate and the incidence rate of adverse reaction in three groups were compared.The expression level of P21,VEGF in three groups before and after treatment were analyzed. Results The total effective rate,chemotherapy sensitivity rate of group A was higher than that of group B and group C respectively(P〈0.05).The incidence rate of adverse reaction of group A was lower than that of group B and group C respectively(P 0.05).The expression level of P21,VEGF after treatment in group A was significantly lower than that in group B and group C respectively(P〈0.05). Conclusion Bingji Yiliu pellet can increase chemotherapy sensitivity and treatment effect of patient with glioma,inhibiting the expression level of P21,VEGF,and promote prognosis of patient.
出处
《中国当代医药》
2014年第36期86-88,共3页
China Modern Medicine
基金
湖南中医药高等专科学校附属第一医院青年科学基金