摘要
目的探讨慢性阻塞性肺疾病(COPD)急性加重期血清白介素-6(IL-6)表达变化及其肺炎衣原体感染的相关性,以对COPD进行有针对性的控制。方法选取2012年5月-2014年5月医院收治的98例COPD患者,将其设为观察组,其中45例患者处于稳定期,53例患者处于急性加重期,另选取同期来医院进行健康体检的45人作为对照组,对比各组间指标的差异。结果 COPD急性加重期和稳定期患者的血清IL-6含量均明显高于对照组(P<0.05),而COPD急性加重期患者的IL-6含量明显比稳定期患者高(P<0.05);COPD急性加重期、稳定期患者及对照组人员肺炎衣原体感染的急性感染率分别为35.8%、11.1%、8.9%,慢性感染率分别为41.5%、28.9%、0;COPD急性加重期患者肺炎衣原体感染的急性感染率均明显高于COPD稳定期和对照组(P<0.05),COPD急性加重期和稳定期患者肺炎衣原体感染的慢性感染率均明显高于对照组(P<0.05);COPD急性加重期患者lgG、lgA的GMT均明显高于COPD稳定期和对照组(P<0.05),而COPD稳定期患者的lgA的GMT明显高于对照组(P<0.05),但二者之间的差异无统计学意义;肺炎衣原体lgA的GMT和血清IL-6呈显著正相关关系(P<0.05),但lgG、lgM的GMT和血清IL-6无相关性。结论 COPD急性加重期肺炎衣原体lgA的GMT和血清IL-6呈显著的正相关关系。
OBJECTIVE To explore the correlation between the change of expression of serum interleukin-6（IL-6）and the Chlamydia pneumoniae infections in patients with acuter exacerbation of chronic obstructive pulmonary disease（COPD）so as to provide guidance for targeted control of COPD.METHODS A total of 98 patients with COPD who were treated in the hospital from May 2012 to May 2014 wee enrolled in the study and assigned as the observation group,including 45 cases in stable stage and 53 cases in acute exacerbation stage;meanwhile,45 healthy people who underwent physical examination were set as the control group;the difference in the indicators was observed and compared.RESULTS The serum IL-6content was significantly higher in the COPD patients in acute exacerbation stage or stable stage than in the patients of the control group（P〈0.05）,while the serum IL-6content of the COPD patients in acute exacerbation stage was significantly higher than that of the COPD patients in stable stage（P〈0.05）.The incidence rate of acute C.pneumoniaeinfection was 35.8%in the COPD patients in acuter exacerbation stage,11.1%in the COPD patients in stable stage,8.9%in the patients of the control group;the incidence rate of chronic infection was 41.5%in the COPD patients in acute exacerbation stage,28.9%in the COPD patients in stable stage,0in the patients of the control group;the incidence rate of acute C.pneumoniaeinfection was significantly higher in the COPD patients in acute exacerbation stage than in the COPD patients in stable stage and the patients of the control group（P〈0.05）;the incidence rate of chronic Chlamydia pneumoniae infection was significantly higher in the COPD patients in acute exacerbation stage or in stable stage than in the patients of the control group（P〈0.05）.The GMT of lgG or lgA of the COPD patients in acute exacerbation stage was significantly higher than that of the COPD patients in stable stage and the patients of the control group（P〈0.05）,however,the GMT of lgA of the COPD patients in stable stage was significantly higher than that of the patients of the control group（P〈0.05）,The GMT of lgA of C.pneumoniae was positively correlated with the serum IL-6（P〈0.05）,while the GMT of lgG or lgM was not correlated with the serum IL-6.CONCLUSION The GMT of lgA of C.pneumoniaein the COPD patients in acute exacerbation stage is positively correlated with the serum IL-6.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第2期247-249,共3页
Chinese Journal of Nosocomiology
基金
河北省卫生厅基金资助项目(20100046)
关键词
慢性阻塞性肺疾病
急性加重期
血清白介素-6
Chronic obstructive pulmonary disease
Acute exacerbation
Serum interleukin-6
