摘要
目的探讨手足口病患儿血清变化的临床意义及护理干预的有效方法,为提高临床诊治水平提供参考。方法通过测定手足口病患儿急性期42例、恢复期37例血清变化与同期健康儿童35名作对照,比较两组白介素1β(IL-1β)、白介素6(IL-6)、白介素12(IL-12)以及肿瘤坏死因子α(TNF-α)水平。结果手足口病患儿发病急性期IL-1β、IL-6、IL-12及TNF-α水平均高于对照组,差异有统计学意义(P<0.01),而恢复期IL-1β、IL-6、IL-12及TNF-α水平与对照组比较差异无统计学意义;普通组IL-1β、IL-6、IL-12及TNF-α水平均高于重症组,差异有统计学意义(P<0.01),而重症组IL-1β、IL-6、IL-12及TNF-α水平与对照组比较差异无统计学意义。结论手足口病患儿感染病毒后,细胞免疫功能受到影响,急性期细胞因子IL-1β、IL-6、IL-12以及TNF-α升高,有助于机体早期启动特异性和非特异性免疫,调动各类免疫细胞参与肠道病毒的免疫;采取积极有效的护理措施,提供有利的免疫环境,有利于患儿早日康复。
OBJECTIVE To explore the clinical significance of change of serum in children with hand,foot,and mouth disease and put forward effective nursing interventions so as to improve the clinical diagnosis and treatment.METHODS The serum of 42 children with hand,foot,and mouth disease at acute phase,37 children with hand,foot,and mouth disease at recovery phase,and 35 healthy children was determined and compared;the levels of the interleukin 1β（IL-1β）,interleukin 6（IL-6）,interleukin 12（IL-12）,and tumor necrosis factorα（TNF-α）were compared between the two groups.RESULTS The levels of the IL-1β,IL-6,IL-12,and TNF-αof the children with hand,foot,and mouth disease at acute phase were higher than those of the children in the control group,there was significant difference（P〈0.01）;there was no significant difference in the level of IL-1β,IL-6,IL-12,or TNF-αbetween the children with hand,foot,and mouth disease at acute phase and the children in the control group;the levels of the IL-1β,IL-6,IL-12,and TNF-αwere higher in the common group than in the severe group,the difference was significant（P〈0.01）;there was no significant difference in the level of IL-1β,IL-6,IL-12,or TNF-αbetween the severe group and the control group.CONCLUSIONThe cellular immune functions of the children with hand,foot,and mouth disease can be influenced after they are infected with virus,the elevated levels of cytokines IL-1β,IL-6,IL-12,and TNF-αat acute phase may facilitate the initiation of specific and nonspecific immunity in early stage and mobilize various immune cells to involve in the immune of enterovirus.It is an effective way to take the nursing interventions and offer favorable immune function so as to benefit the early rehabilitation of the children.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第2期452-454,共3页
Chinese Journal of Nosocomiology
基金
山东省自然科学基金资助项目(ZR2010HM075)
关键词
手足口病
血清
护理
Hand
foot
and mouth disease
Serum
Nursing
