摘要
目的 对比分析影响新疆维（维吾尔族）、汉族女性乳腺癌患者术后复发及远处转移的危险因素。方法 收集汉族和维族临床诊断为Ⅰ～Ⅲ期可手术乳腺癌患者的完整临床资料进行回顾性分析,并对影响复发转移的危险因素进行单因素及多因素logistic回归分析。结果 共纳入728例患者,维、汉族女性乳腺癌术后3年内发生复发转移率分别为28.4%、9.8%;其中局部复发者维吾尔族组11例（6.5%）,汉族组9例（1.6%）;远处转移者维吾尔族组37例（21.8%）,汉族组45例（8.0%）。维、汉族女性在肿瘤大小、出现症状至就诊时间差异有统计学意义（P〈0.05）。病理类型、肿瘤大小、腋窝淋巴结转移情况、临床分期、ER及PR表达情况、术后是否接受正规的辅助治疗是影响Ⅰ～Ⅲ期手术乳腺癌患者复发及远处转移的相关因素（P〈0.05）。多因素logistic回归分析结果显示,维吾尔族乳腺癌患者复发转移率高于汉族乳腺癌患者,其差异有统计学意义（P〈0.01）;病理分型、肿瘤大小、腋窝淋巴结转移数是预测维、汉族乳腺癌患者术后复发转移的危险因素,而ER阳性表达、术后辅助放化疗是保护因素。结论 维吾尔族乳腺癌患者复发转移率高于汉族乳腺癌患者;病理分型、肿瘤大小、腋窝淋巴结转移数是乳腺癌复发及远处转移的危险因素,而ER阳性表达、术后辅助放化疗可能抑制乳腺癌的复发及远处转移。
Objective To comparatively analyze risk factors that influence the postoperative recurrence and distant metastasis between Xin）iang Uygur and Han women with breast cancer. Methods The clinical data of Han and Uyghur women with diagnosis of breast cancer at I-III period were completely collected for retrospective analysis. Then logistic regression （univariate and multivariate） was performed for analyzing the risk factors that influenced recurrence and metastasis. Results A total of 728 patients were included. The recurrence and metastasis rates among Uyghur and Han patients 3 years after surgery were 28.4%, 9.8%, respectively, including local recurrence Ill Uyghur cases （6.5%） and 9 Han cases （1.6%）] and distant metastasis [37 Uyghur cases （21.8%） and 45 Han cases （8.0%）]. Significant differences were found between the two groups in tumour size and time from symptom occurrence to clinical visits （P〈0.05）. Pathological type, turnout size, axillary lymph node metastasis, clinical stage, ER and PR expression, and whether to accept a regular postoperative adjuvant therapy were associated with the recurrence and metastasis rate among the patients with breast cancer at I-III period （P〈0.05）. The results of multivariate logistic regression analysis showed that, the recurrence and metastasis rate of Uyghur patients was higher than that of Han patients with a significant difference （P〈0.01）. Pathological type, tumour size, and axillary lymph node metastasis number were the risk factors used to predict postoperative recurrence and metastasis among Uygur and Han patients; while ER positive expression, adjuvant radiation and postoperative chemotherapy were protective factors. Conclusion The recurrence and metastasis rate of Uyghur patients with breast cancer is higher than that of Han patients. Pathological type, tumour size, and axillary lymph node metastasis number are the risk factors of postoperative recurrence and distant metastasis; while ER positive expression, adjuvant radiation and postoperative chemotherapy may inhibit the recurrence and distant metastasis of breast cancer.
出处
《中国循证医学杂志》
CSCD
2015年第1期8-11,共4页
Chinese Journal of Evidence-based Medicine
基金
国家自然科学基金资助项目(编号:30960376)
关键词
乳腺癌
复发转移
危险因素
维吾尔族
汉族
横断面研究
Breast cancer
Recurrence and metastasis
Risk factor
Uyghur nationality
Han nationality
Crosssectional study
