摘要
目的：探讨帕瑞昔布钠超前镇痛对腹腔镜胆囊切除术患者的疗效及安全性。方法：68例腹腔镜胆囊切除术患者随机分为观察组与对照组各34例。两组患者均采用气管插管全身麻醉下行腹腔镜胆囊切除术，术后采用瑞芬太尼自控镇痛。观察组麻醉诱导前予帕瑞昔布钠40mgiv，手术结束时予0．9％氯化钠注射液2ml iv；对照组麻醉诱导前予0．9％氯化钠注射液2mliv，手术结束时予帕瑞昔布钠40mgiv。比较两组患者术后1h（T1）、术后2h（T2）、术后8h（T3）、术后12h（T4）及术后24h（T5）的疼痛评分，观察两组自控镇痛及不良反应发生情况。结果：观察组患者T1～L5各时间点VAS评分均优于对照组（P〈0．05），患者术后24h内PCIA按压次数和有效按压次数也明显少于对照组（P〈0．05）。两组药品不良反应发生率比较，差异无统计学意义（P〉0．05）。结论：腹腔镜胆囊切除术患者麻醉诱导前应用帕瑞昔布超前镇痛较术后应用镇痛效果更佳，安全有效，可减少术后镇痛泵用量。
Objective： To discuss curative effect and security of parecoxib sodium applied on laparoscopic chole- cystectomy （LC）. Methods ：68 cases of patients with LC were divided into observation group and control group at random. The patients in two groups were given LC by general anesthesia tracheal intubation, which were given remifentanil after the operation. The patients in observation group were given parecoxib sodium 40mg iv before anesthesia induction, as well as 0.9% sodium chloride injection （NS） 2ml iv upon the completion of operation, while the patients in control group were given 2ml NS iv before anesthesia induction, as well as parecoxib sodium 40mg upon the completion of operation. The visual analog scale （VAS） of patients in two groups were observed at the following times ： 1 h （ T1 ）, 2h （ T2 ）, 8h （ T3 ）, 12h （ T4 ） and 24h （T5） ＇after the operation, and the PCIA and adverse drug reactions in two groups were observed as well. Re- suits：The VAS of patients in observation group at T1 , T2 , T3 , T4 and T5 were better than those in control group （P 〈 0.05 ） , and the PCIA press times and effective press times of patients in observation group within 24 hours after the opera- tion were much less than those in control group （P 〈 0.05 ）. There were no statistically significant difference between the occurrence rates of adverse drug reactions of patients in the two groups （ P 〉 0.05 ）. Conclusion ： The application of pare- coxib sodium preemptive analgesia before the anesthesia induction can receive more favorable VAS effect, which can reduce the use frequency of postoperative analgesia pump. And it is a safe and effective nreemntive analgesia method.
出处
《药物流行病学杂志》
CAS
2015年第1期9-11,共3页
Chinese Journal of Pharmacoepidemiology
关键词
帕瑞昔布钠
超前镇痛
腹腔镜胆囊切除术
疗效
安全性
Parecoxib
Preemptive analgesi
Laparoscopic cholecystectomy
Curative effect
Security
