摘要
目的随着宫颈癌发病率的逐年上升,中药在治疗宫颈癌放化疗副反应及术后并发症中的作用逐渐被重视。大量研究发现诱导宫颈癌Hela细胞凋亡可以通过影响Bcl-2基因家族、Caspase蛋白酶家族、Fas/Fasl基因系统、某些相关基因的表达等方式来实现。文章从目前国内外研究比较热门的一些中药入手,综述这些中药的有效成分在宫颈癌Hela细胞凋亡中的作用。例如文中提到中药温莪术有效成分β-榄香烯是通过下调Bcl-2基因表达来促进Hela凋亡;栝楼根的有效活性成分天花粉蛋白促凋亡过程与Caspase家族有关;薏苡仁酯诱导Fas表达上调、Fasl表达下调来促进宫颈癌Hela细胞凋亡。研究中药有效成分影响宫颈癌Hela细胞凋亡机制的目的是为临床应用中药治疗宫颈癌提供科学依据和筛选抗宫颈癌新药提供思路。
With the increasing of cervical cancer incidence , the effects of Chinese medicinals in treating cervical cancer radiotherapy and chemotherapy side reaction and postoperative complications were gradually attached importance to .Influencing Bax/Bcl-2 family, Caspase family , Fas/Fasl system and the expression of some related genes could induce cervical cancer Hela cells apoptosis .This article focuses on several kinds of Chinese medicinals , summarizes the faction of the mechanism of effective constituent of these Chinese medicinals in cervical cancer Hela cells apoptosis .For example , the effective constituent of curcuma zedoaria promotes Hela cell apoptosis by down-regulated expression of Bcl-2.The procedure of promoting He-la cell apoptosis of Trichosanthin has relationship with Caspase famlily .The purposes of researching Chinese medicine effective constituent influnes cervical cancer Hela cell apoptosis are providing the scientific basis for treating cervical cancer with Chinese medicine and ideas about filtering new medicines for the cancer .
出处
《环球中医药》
CAS
2015年第1期124-127,共4页
Global Traditional Chinese Medicine
基金
国家自然科学基金(30770573/31170806)
北京市自然科学基金(7092013)
沈阳市科技攻关计划(F12193948)
关键词
中药有效成分
宫颈癌HELA细胞
细胞凋亡机制
综述
Effective constituent of Chinese medicinals
Cervical cancer Hela cells
Cells apoptosis
Review
