摘要
目的:观察308 nm准分子光联合外用复方补骨脂酊治疗内蒙古地区稳定期白癜风的疗效。方法:选取稳定期白癜风患者60例,共133片皮损。将其随机分成2组:A组单用308 nm准分子光治疗;B组给予308 nm准分子光联合复方补骨脂酊治疗。复方补骨脂酊治疗每日两次,光疗频率每周1次,10次一疗程,共2疗程,每次疗程结束后拍照、疗效评价,记录结果。结果:治疗10次后,A组的有效率和显效率分别为17.46%和4.76%,B组分别为20.00%和5.71%;治疗20次后,A组的有效率和显效率分别为46.03%和23.81%,B组分别为65.71%和42.86%。两组治疗10次后的有效率和显效率比较差异均无统计学意义(P>0.05),治疗20次后的有效率和显效率均显著高于其治疗10次后(P<0.05),B组治疗20次后的有效率和显效率均显著高于A组(P<0.05)。所有患者的皮损均未出现严重不良反应。结论:308 nm准分子光联合复方补骨脂酊外用可提高内蒙地区白癜风患者颈、躯干、四肢的非关节、非肢端及非骨隆起部位的白斑的疗效,且安全性较好。
Objective： To compare the efficacy of 308 nm excimer lamp alone and 308 nm excimer lamp combined with psoraleae tincture in the treatment of vitiligo in inner Mongolia. Methods： 60 cases of patients with vitiligo in stationary phases were enrolled（133 lesions were included）, and randomly divided into 2 groups. The group A was treated with 308 nm excimer lamp alone,while the group B was treated with 308 nm excimer lamp combined with psoraleae tincture. All the lesions were treated once a week,topicas were used twice a day, all lesions were taken photos every ten times. Results： After ten times＇ treatment, the effective rate and significant rate of group A were 17.46% and 4.76% respectively, which were 20.00% and 5.71% in group B; after twenty times＇ treatment, the effective rate and significant rate of group A were 46.03% and 23.81%, which were 65.71% and 42.86% in group B. There was no significant difference between 2 groups in the effective rate and significant rate after ten times＇ treatment（P〉0.05）, but the effective rate and significant rate after twenty times＇ treatment were obviously higher than those after ten times＇ treatment（P〈0.05）, and the effective rate and significant rate of group B were obviously higher than those of group A after twenty-times＇ treatment（P〈0.05）. No lesion experienced serious adverse reactions. Conclusion： 308 nm Excimer Lamp combined with psoraleae tincture could significantly improve the efficacy of lesions on neck, truck and limbs（non-articulus, non-outlimb and non-eminence of bone） of vitiligo in inner Mongolia, and had good safety.
出处
《现代生物医学进展》
CAS
2014年第35期6880-6882,6892,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81160189)
