摘要
目的:研究早期检测高敏肌钙蛋白对预测及诊断急性冠脉综合征的价值。方法:以2012年1月至2014年07月于我院就诊的82例疑似急性冠脉综合征患者为研究对象,采集血液标本,均分为两组,一组行血清常规肌钙蛋白T(c Tn T)检测,结果归入对照组;一组行血清高敏肌钙蛋白(hs-c Tn I)检测,结果归入观察组。同时行心肌酶谱及心电图检查,以其动态演变为金标准,评价两组敏感度、特异度,绘制ROC曲线。结果:金标准提示共64例阳性患者。观察组检测hs-c Tn I阳性62例,敏感度92.2%(59/64),特异度88.9%(16/18);对照组检查c Tn T阳性59例,敏感度79.7%(51/64),特异度55.6%(10/18),观察组ROC曲线优于对照组(P=0.000)。健康人群肌钙蛋白含量显著性低于急性冠脉综合征患者,差异具备统计学意义(P<0.05)。结论:hs-c Tn I检测有助于预测急性冠脉综合征,其诊断敏感度及特异度均较高,可满足现阶段诊治需求。
Objective： To Study the value of early detection of high sensitivity troponin＇s in prediction and diagnosis of acute coronary syndrome. Methods： 82 cases of patients with suspected acute coronary syndrome in our hospital from January 2012 to December 2014 were selected as the research objects. The blood specimens were collected, and the normal serum troponin T（c Tn T） was tested, then the results were placed in control group; while the serum high sensitivity troponin（hs-c TnI） was tested, and the results was set in observation group. At the same time, electrocardiogram（ecg） and myocardial enzyme spectrum examination were conducted, and its dynamic evolution was used as the gold standard to evaluate the sensitivity and specific degrees of the two groups were evaluated and to make ROC curve. Results： The gold standard suggested that a total of 64 patients were positive. In the observation group, 62 cases of hs-c TnI were detected positive, and the sensitivity was 92.2 %（59/64）, the specificity was 88.9 %（16/18）; while in the control group, 59 cases of c Tn T were positive, and the sensitivity was 79.7 %（51/64）, and the specificity was 55.6 %（10/18）. The ROC curve of observation group was better than that of the control group（P=0.000）. The troponin level of healthy people was significantly lower than that of patients with acute coronary syndrome, and the differences are statistically different（P〈0.05）. Conclusion： Hs-c TnI detection can contribute to predict acute coronary syndrome which has a high diagnostic sensitivity and specificity, and can meet the demand of current diagnosis and treatment.
出处
《现代生物医学进展》
CAS
2014年第35期6886-6888,共3页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81170220)
