摘要
The optical fiber nanoprobe is prepared using spark fused taper and acid corrosion methods. With 3-aminopropyltrimethoxysilane coupling, gold nanoparticles are solidified onto the surface of fiber optic and then the optical fiber sensor is prepared using the surface-enhanced Raman spectroscopy （SERS） measurement of the cell solution. The SERS of the esophageal cancer cell solution is measured by direct detection and fiber detection methods. Similar results are obtained by both detection methods. SERS measurement of tissues and organs is done using the optical fiber sensor.
The optical fiber nanoprobe is prepared using spark fused taper and acid corrosion methods. With 3-aminopropyltrimethoxysilane coupling, gold nanoparticles are solidified onto the surface of fiber optic and then the optical fiber sensor is prepared using the surface-enhanced Raman spectroscopy （SERS） measurement of the cell solution. The SERS of the esophageal cancer cell solution is measured by direct detection and fiber detection methods. Similar results are obtained by both detection methods. SERS measurement of tissues and organs is done using the optical fiber sensor.
基金
This work was financially supported by the National Natural Science Foundation of China （Nos. 61027015, 61177088, and 61107076）, the National 973 Program of China （No. 2012CB723405）, and the Key Laboratory of Specialty Fiber Optics and Optical Access Networks （Nos. SKLSFO2012-01 and SKLSFO2013-02）.
