摘要
背景:采用自体微粒皮移植异体皮覆盖已成为近来修复特重度烧伤患者创面的主要手段。由于异体皮来源极为困难,因此,临床上采用异种皮(猪皮)或人工皮作为载体来覆盖创面。目的:观察薄中厚微粒皮皮浆移植异种皮覆盖修复烧伤创面的疗效及创面愈合后的皮肤质量,并与刃厚微粒皮皮浆移植异种皮覆盖的临床疗效进行对比。方法:选取特重度具有双侧肢体烧伤的患者36例,采用自身对照的方法,选择可供对比的创面42对,其中关节部位32对。每例患者选取1至2对肢体烧伤程度较为相同的Ⅲ度切痂创面进行对比。在异种皮覆盖下,试验组采用薄中厚微粒皮皮浆涂抹移植修复烧伤创面,对照组采用刃厚微粒皮皮浆涂抹移植修复烧伤创面,两组供皮区与受皮区面积之比相同(所有患者扩张比控制在1∶8-1∶12)。观察创面愈合时间、移植后半年至2年创面愈合后的瘢痕增生程度、关节部位需整复手术的比率,对手术切除的瘢痕按温哥华瘢痕量表总评分进行对比分析。结果与结论:试验组创面平均愈合时间(44.7±1.24)d,明显短于对照组创面平均愈合时间(49.6±1.41)d(P<0.05)。试验组移植后半年至2年创面愈合后的瘢痕增生程度轻于对照组:重度瘢痕增生的比率明显小于对照组(P<0.05),轻度瘢痕增生的比率明显大于对照组(P<0.01),两组中度瘢痕增生的比率相近(P>0.05)。试验组关节部位需整复手术的比率为38%,明显低于对照组59%(P<0.01)。试验组手术切取瘢痕的温哥华瘢痕量表总评分明显低于对照组(P<0.05)。提示在异种皮覆盖下,通过增加微粒皮厚度,采用薄中厚微粒皮浆移植是修复大面积全层皮肤烧伤的较好方法,可获得较好的创面愈合质量。
BACKGROUND：Autologous micro-skin graft covered with alogeneic skin has become a major means for repair＆amp;nbsp;of extremely severe burn wounds. Due to the limitation of the source of alogeneic skin, heterogeneous skin （pigskin） or artificial skin serves as a vector to cover the wound on the clinical use. OBJECTIVE： To observe the curative effect of thin-thickness micro-skin pulping covered with heterogeneous skin for repair of burn wounds in comparison with blade-thickness micro-skin pulping covered with heterogeneous skin. METHODS：A self-control study was performed in 36 patients with severe burns of bilateral limbs. There were 42 pairs of wounds, 32 of which were at joint sites. One or two pairs of III-degree burns treated with escharectomy were selected from each patient for self-control comparison. Covered with heterogeneous skin, thin-thickness micro-skin pulping and blade-thickness micro-skin pulping were used in the trial and control groups, respectively. The expansion ratio was controled at 1：8-1：12 in al patients. Wound healing time, degree of scar hyperplasia within 6 months to 2 years after transplantation, and ratio of reconstruction surgery at joint sites were observed and compared. The removed scars by surgery were analyzed based on the total score of the Vancouver Scar Scale. RESULTS AND CONCLUSION： The average wound healing time was （44.7±1.24） days in the trial group and （49.6±1.41） days in the control group, and there was a significant difference between the two groups （P 〈 0.05）. The trial group exhibited less scar hyperplasia than the control group at 6 months to 2 years after transplantation. Compared with the control group, the ratio of severe scar hyperplasia was significantly less in the trial group （P 〈 0.05）, while the ratio of mild scar hyperplasia was obviously greater in the trial group （P 〈 0.01）. However, there was no difference in the ratio of moderate scar hyperplasia between the two groups （P 〉 0.05）. The reconstructive surgery ratio of the trial group was 38%, significantly lower than that of the control group （59.38%;P 〈 0.01）. The total score on the Vancouver Scar Scale was less in the trial group than the control group （P 〈 0.05）. These findings suggest that the thin-thickness micro-skin covered with heterogeneous skin is likely to be a better treatment to repair large ful-thickness skin burn by increasing the thickness of micro-skin, and it can obtain better wound healing quality.
出处
《中国组织工程研究》
CAS
CSCD
2014年第46期7417-7421,共5页
Chinese Journal of Tissue Engineering Research
基金
河北省卫生厅
重点科技研究计划自筹基金项目(20130663)~~
