摘要
目的:探讨乳腺癌超声造影特征与C-erbB-2及nm23的阳性表达之间的关系。方法:回顾性分析乳腺癌患者超声造影资料与术后C-erbB-2及nm23的免疫组化结果,将造影的各个指标及参数与C-erbB-2及nm23的表达之间的关系进行统计分析。结果:169例乳腺癌病灶中,C-erbB-2的阳性率及nm23的阳性率分别为66.7%(46/69)、27.5%(19/69),在C-erbB-2阳性者中的nm23的阳性表达率为13.0%(6/46),高于C-erbB-2阴性者中nm23的阳性表达率(56.5%,13/23),差异有统计学意义(P=0.029)。2C-erbB-2表达阳性组中,病灶多表现为高增强、不均匀增强或病灶中央出现灌注缺损区、病灶边缘多表现为放射状增强,在时间强度曲线上显示较高的相对上升斜率及相对达峰强度,与C-erbB-2表达阴性组比较,差异有统计学意义(P<0.05)。3在nm23表达阴性的病灶中,病灶多表现为高增强、病灶边缘多表现为放射状增强,其时间强度曲线显示较高的相对上升斜率,与nm23表达阳性组比较,差异有统计学意义(P<0.05)。结论:乳腺癌超声造影的某些特征与C-erbB-2、nm23等分子生物学指标有一定的关系,可以协助临床预测患者预后。
Objective： To discuss the relationship between the contrast-enhanced ultrasound （CEUS） images of the breast cancers and the molecular biology markers of C-erbB-2 and nm23. Methods： The imaging data of CEUS in breast cancer, C-erbB-2 and nm23 immunohistochemical results after operation were ana＇lysed retrospectively. Correlation between CEUS in- dexes or parameters and the expression of C-erbB-2 and nm23 were also studied. Results： （~）The positive expression rate of C-erbB-2 and nm23 in breast cancer were 66.7%（46/69） and 27.5%（19/69） respectively. The positive expression of nm23 in the group with C-erbB-2 positive expression was 13%, which was higher than that in the group with C-erbB-2 negative ex- pression. （~）In the group with C-erbB-2 positive expression, lesions showed high enhancement, heterogeneous enhancement or lesions with perfusion defect area, peripheral radial enhanement, relative rising slope and relative peak intensity showed signif- icant differences in the time intensity curves, compared with the group with C-erbB-2 negative expression（P〈0.05）. In nm23 negative group, the lesion showed high enhancement, peripheral radial enhancement, and the time intensity curve showed high- er relative rising slope with statistical significance （P〈0.05） compared with the nm23 positive group. Conclusion： Some con- trast-enhanced ultrasound features correlated with C-erbB-2 and nm23 expression in breast cancer, which could be useful to predict the prognosis of patients to some extent.
出处
《中国临床医学影像杂志》
CAS
2014年第11期764-767,771,共5页
Journal of China Clinic Medical Imaging
关键词
乳腺肿瘤
超声检查
多普勒
彩色
Breast neoplasms
Uhrasonography, Doppler, color
