摘要
骨质疏松症是一种以骨量低下、骨微结构破坏为特征,骨脆性增加、易发生骨折等的代谢性疾病。其发病病因多样,分子机制复杂,已成为影响人们生活质量的流行病之一。人体生活在一个充满氧气的环境,在其代谢过程中不可避免的不断产生活性氧(ROS),当人体因为衰老、疾病等原因产生ROS与消除ROS之间的平衡被打破时,机体便产生氧化应激。越来越多的研究发现ROS诱导的氧化应激在骨质疏松症中发挥重要作用,过多的ROS通过对多种细胞因子、酶活性的激活或抑制和上调或下调受体配体的表达调控多条信号通路,最终影响细胞核内基因表达,促进骨形成相关细胞如骨髓间充质干细胞(BMSCs)、成骨细胞、骨细胞的凋亡和破骨细胞的增殖及分化,使得骨形成速率相对骨吸收速率滞后,打破以破骨细胞吸收骨组织和成骨细胞形成骨组织相协调的动态平衡过程,从而促使骨质疏松症的产生。本文从ROS诱导的氧化应激对骨形成相关细胞、破骨细胞和骨基质的影响展开综述,为骨质疏松症的进一步研究提供依据。
Osteoporosis is a kind of metabolic disease characterized by bone mass loss and bone microstructure destruction, leading to fragility of the bone and increase of bone fracture risk.The disease has become one of the popular diseases that affect people’ s quality of life.Its etiology is various and molecular mechanism is complex.Continuous formation of ROS is an inescapable consequence of the human metabolism in an oxygen-rich environment.Oxidative stress occurs in the condition that the ROS balance between generation and elimination is broken because of aging, disease and so on in the human body.More and more studies have found that oxidative stress induced by excessive ROS plays an important role in osteoporosis.Excessive ROS regulates multiple signaling pathways via a variety of cytokines, the activation or inhibition of enzyme activity, and up-regulation or down-regulation of the expression of receptor ligand.Ultimately it affects the gene expression within the nucleus, promotes apoptosis of bone formation related cells such as bone marrow mesenchymal stem cells （ BMSCs） , osteoblasts, and osteocytes, promotes proliferation and differentation of osteoclasts, and results in the lag of bone formation behind bone resorption.As a result, the dynamic balance between osteoclastic bone resorption and osteoblastic bone formation is broken, leading to osteoporosis.This article reviewes the effect of oxidative stress induced by ROS on bone formation related cells, osteoclasts, and bone matrix, and provides a basis for the further research of osteoporosis.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2014年第12期1485-1489,共5页
Chinese Journal of Osteoporosis
基金
江西省自然科学基金资助项目(20114BAB205073)
江西省卫生厅中医药科研项目(2011A142
2012A031)
江西中医学院重点学科培养计划资助项目(2012jzzdxk004)
