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阻塞性睡眠呼吸暂停低通气综合征与高血压关系的研究进展 被引量:25

Research progress of obstructive sleep apnea syndrome and hypertension
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摘要 睡眠呼吸暂停综合征是一种睡眠时呼吸停止的睡眠障碍.最常见的原因是上呼吸道阻塞,经常以大声打鼾、身体抽动或手臂甩动结束,主要以睡眠中反复发作的呼吸暂停或低通气导致的低氧血症及高碳酸血症为特点.主要分为中枢型、阻塞型及混合型,其中以阻塞性睡眠呼吸暂停综合征(OSAS)最为常见,是多种全身性疾病的危险因素,肥胖、年纪大、肌肉松弛的人群高发.多导睡眠图(PSG)是诊断此病的金标准,量化指标是呼吸暂停低通气指数(AHI)及夜间最低血氧饱和度.研究表明,OSAS常与高血压、冠心病、脑卒中等疾病并存[1],这一现象受到越来越多的心脑血管专家的关注.值得指出的是,流行病学及临床研究证实OSAS与高血压之间存在密切因果关系[2-4].本文主要就阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与高血压的关系进行综述.
出处 《中国心血管病研究》 CAS 2015年第1期5-7,共3页 Chinese Journal of Cardiovascular Research
基金 国家自然科学基金(项目编号:81360037) 云南省自然科学基金(项目编号:2012FB009,2013FZ284)
关键词 阻塞性睡眠呼吸暂停综合征 高血压 发病机制 诊治 Obstructive sleep apnea syndrome Hypertension Pathogenesis Diagnosis and treatment
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  • 1Stern MP, Williams K, Gonzdlez-Villalpando C, et al. Does the metabolic syndrome improve identification of individuals at risk of type 2 diabetes and/or cardiovascular disease? Diabetes Care, 2004,27 : 2676-2681.
  • 2Silverberg DS, Oksenberg A, Iaina A. Sleep-related breathing disorders as a major cause of essential hypertension:fact or fic- tion? Curt Opin Nephrol Hypertens, 1998,7 : 353-357.
  • 3Nieto FJ, Young TB, Lind BK, et al. Association of sleep-dis- ordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA, 2000,283 : 1829-1836.
  • 4Young T, Peppard P, Paha M, et al. Population-based study of sleep-disordered breathing as a risk factor for hypertension. Arch Intern Med, 1997,157 : 1746-1752.
  • 5Punjabi NM, Caffo BS, Goodwin JL, et al. Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med, 2009,6 : e1000132.
  • 6Yaggi HK, Concato J, Kernan WN, et al. Obstructive sleep ap- nea as a risk factor for stroke and death. N Engl J Med, 2005,353 : 2034-2041.
  • 7Somers VK, White DP, Amin R, et al. Sleep apnea and cardio- vascular disease: an American Heart Association/American Col- lege Of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Re- search Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council On Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (Na- tional Institutes of Health). Circulation,2008,118:1080-1111.
  • 8Troncoso Brindeiro CM, da Silva AQ, Allahdadi K J, et al. Reac- tive oxygen species contribute to sleep apnea-induced hypertention in rats. Am J Physiol Heart Circ Physiol, 2007,293:H2971-2976.
  • 9O'Connor GT, Carlo B, Newman AB, et al. Prospective study of sleep-disordered breathing and hypertension. Am J Respir Crit.Care Med, 2009,179 : 1159-1164.
  • 10Loredo JS, Ancoli-Israel S, Dimsdale JE. Sleep quality and blood pressure dipping in obstructive sleep apnea. Am J Hypertens, 2001,14 : 887-892.

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