摘要
目的:探讨内源性分泌型晚期糖基化终产物受体(esRAGE)及可溶性晚期糖基化终产物受体(sRAGE)与2型糖尿病合并冠心病患者药物支架内再狭窄的关系。方法:共有76例患者纳入研究,2型糖尿病合并支架内再狭窄38例(T2D-ISR组),2型糖尿病不伴支架内再狭窄38例(对照组)。采集患者静脉血,检测血清sRAGE和esRAGE水平以及总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白-胆固醇(LDL-C)、血糖(Glu)、肌酐(Cr)、糖化血红蛋白(HbA1c)以及C反应蛋白(CRP)水平。结果:两组患者基线特征差异无统计学意义;T2DISR组血清esRAGE水平明显低于对照组(P=0.000 8),esRAGE水平与CRP浓度呈负相关(r=-0.38,P=0.02);两组sRAGE水平差异无统计学意义。结论:低水平的esRAGE与2型糖尿病合并支架内再狭窄相关,esRAGE水平与CRP浓度呈负相关性,糖基化保护因素减弱,是2型糖尿病合并支架内再狭窄的易感因素。
Objective：To explore the relationship between esRAGE,sRAGE and in-stent restenosis in patients with type 2 diabetes （T2D）with drug-eluting coronary stents. Method：We enrolled 38 T2D patients with in-stent restenosis （ISR） （T21-ISR group） and 38 T2D patients without ISR （control group）. Plasma levels of esRAGE, sRAGE, total cholesterol （TC）, triglyceride （TG）, low density lipoprotein-cholesterol （LD1.-C）, blood glucose, creatinine, glycated hemoglobin （HbA1 c） and C-reactive protein （CRP） were measured. Result： Baseline character~ istics showed no difference between two groups. Plasma level of esRAGE was significantly lower in T2D-ISR group than that in control group, the level of esRAGE was negatively correlated with CRP concentration（r= 0. 38,P= 0. 02）. sRAGE level did not reach statistical difference between two groups. Conclusion： Plasma level of esRAGE may be negatively associated with ISR, and the level of esRAGE is negatively correlated with CRP con- centration. The less protection of glycosylation is a susceptibility factors of in-stent restenosis in patients with T2D.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2014年第12期1056-1058,共3页
Journal of Clinical Cardiology
基金
国家自然科学基金项目(No:81270314)
上海市科委项目(No:134119a3000)
关键词
2型糖尿病
冠心病
支架内再狭窄
内源性分泌型晚期糖基化终产物受体
可溶性晚期糖基化终产物
type 2 diabetes
coronary heart disease
in-stent restenosis
endogenous secretory receptor for ad-vanced glycation end products
soluble receptor for advanced g[ycat^on end products
