摘要
目的探讨散发性乳腺癌基因BRCA1在乳腺癌组织中的表达与新辅助化疗敏感度的关系。方法应用免疫组化方法,对乳腺癌患者癌组织BRCA1表达情况进行检测,并用同一化疗方案(TEC)对该组患者进行新辅助化疗,分析其与新辅助化疗敏感度的关系。结果乳腺癌患者BRCA1表达阳性患者完全缓解率、部分缓解率、稳定率、进展率分别为24.6%、70.1%、5.2%、0;乳腺癌患者BRCA1表达阴性患者完全缓解率、部分缓解率、稳定率、进展率分别为9.2%、55.6%、31.5%、3.7%。两组相比各项指标比较差异均有统计学意义(P<0.05)。结论 BRCA1表达水平与新辅助化疗敏感度呈显著正相关,BRCA1可能作为一项预测化疗疗效、指导制定合理治疗方案的新指标。
Objective To investigate the relationship between the expression of BRCA1 in the Sporadic breast cancer tissues and the sensitivity to neoadjuvant chemotherapy Methods To detect Expression of BRCA1 was detected by immunohistochemical and the neoadjuvant chemotherapy was given with the same chemotherapy regimens （TEC）.The relationship between BRCA1 expression and efficacy of neoadjuvant chemotherapy was studied.Results The efficacy of breast cancer BRCA1 expression positive patients with complete response,partial response,stable disease and progress disease were 24.6％,70.1％,5.2％,0％ respectively and those of no expression with complete response,partial response,stable disease and progress disease were 9.2％,55.6％,31.5 ％,3.7％ respectively.Efficacy displayed a significant difference between BRCA1 positive and negative subgroup.Conclusion BRCA1 expression has a positive relationship with sensitivity to neoadjuvant chemotherapy,and can be used as a good marker for predicting efficacy of chemotherapy and guiding to establish reasonable treatment plan.
出处
《医学研究杂志》
2014年第12期49-51,共3页
Journal of Medical Research
基金
云南省教育厅科学研究基金资助项目(2011c089)
关键词
乳腺癌
BRCA1基因
新辅助化疗
化疗敏感度
Breast cancer
BRCA1 gene
Neoadjuvant chemotherapy
Chemotherapy sensitivity
