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中枢神经细胞凋亡与吗啡耐受相关性研究进展 被引量：1

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摘要 全球肿瘤发病率持续增高,我国已经成为肿瘤发病人数最多的国家,大多数肿瘤,特别是晚期恶性肿瘤患者,都将因癌性疼痛而服用阿片类药物止痛。长期使用阿片类药物如吗啡时,会导致药物耐受,从而影响吗啡类药物的止痛效果,最终降低和限制了阿片类药物在临床中的使用。关于吗啡药物耐受的神经生理学机制,目前认为是多方面的,而且并没有完全明了。
作者 周亮 孙莉
机构地区 北京协和医学院中国医学科学院肿瘤医院麻醉科
出处 《中国肿瘤临床与康复》 2015年第1期120-123,共4页 Chinese Journal of Clinical Oncology and Rehabilitation
基金 北京市科技计划基金资助项目 No.Z111107067311034
关键词 凋亡 吗啡耐受 中枢神经细胞 Apoptosis Morphine tolerance Central nervous cell
分类号 R96 [医药卫生—药理学]
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参考文献37

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同被引文献16

  • 1罗柏宁,张波,孙庚喜,张中伟,文剑明.中枢神经细胞瘤的临床病理及影像学表现[J].中国临床医学影像杂志,2004,15(12):661-663. 被引量：19
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中国肿瘤临床与康复
2015年 第1期

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